In this study using SEER data, the risk of death from stage 0 breast cancer increased after a diagnosis of an ipsilateral second primary invasive breast cancer, but prevention of these recurrences did not reduce 10-year breast cancer mortality.
This retrospective analysis of patients with prostate cancer found that dose-escalated external-beam radiation therapy was associated with improved survival in intermediate-risk and high-risk, but not low-risk, disease.
This cohort study of patients with incident human papillomavirus (HPV)–related oropharyngeal carcinoma found that although infrequent, persistent HPV type 16 DNA in posttreatment oral rinses is associated with poor prognosis and is a potential tool for long-term tumor surveillance.
This prospective cohort study of patients with breast cancer receiving hypofractionation vs conventional fractionation for whole-breast radiotherapy found that patients receiving hypofractionation had decreased acute pain and fatigue and were bothered less by dermatitis.
In this randomized clinical trial, hypofractionated whole-breast irradiation (WBI) appeared to yield lower rates of acute toxic effects than conventionally fractionated WBI as well as less fatigue and less trouble meeting family needs 6 months after radiation therapy.
In this clinically representative cohort, multigene panel testing for hereditary breast and/or ovarian cancer risk assessment yielded findings likely to change clinical management for substantially more patients than does testing for BRCA1/2 alone.
This case report describes a 29-year-old man with early-onset colorectal cancer who showed a constitutional MLH1 epimutation inherited from his asymptomatic mother, who showed methylation on the same allele but in less than 5% of her somatic cells.
This case report describes a tertiary acquired mutation identified in a clinical lung cancer sample after treatment with a third-generation EGFR tyrosine kinase inhibitor.
This analysis uses regression discontinuity to reexamine results of the Prostate Lung Colorectal and Ovarian cancer screening trial and concludes that using this technique is worthwhile since treatment decisions are often based on discrete cutoffs in continuous data.
In this special communication, Normal Accident Theory, a framework for analyzing failure potential within and between systems, is applied to the complex interdisciplinary practice of clinical oncology to improve health care safety.
Next-generation sequencing has identified new genetic markers that have altered prognosis for patients with chronic lymphocytic leukemia (CLL) at diagnosis. Nabhan and coauthors discuss the various prognostic parameters in CLL, focusing on cytogenetics, cellular-based factors, and gene mutations.
A man in his 70s with a history of myeloid leukemia, prostate cancer, and colonic adenocarcinoma presented with acute-onset blurred vision in the left eye; examination revealed bilateral hypopyon. What is your diagnosis?
The neoadjuvant approach to drug development has great potential, especially when phase 3 trials have adaptive designs that use interim by-treatment information regarding pathological complete response and event-free survival.
This Viewpoint discusses the perception and reality of breast cancer incidence in young women and the medical and psychosocial challenges that are unique to young women with breast cancer or accentuated by their age.
This viewpoint examines the positive and negative aspects of broad vs narrow testing for precision cancer medicine.
This Invited Commentary highlights the importance of hypofractionation dosing for radiation treatment of early-stage breast cancer.
This Invited Commentary outlines the benefits and challenges of multigene testing, which is rapidly becoming the norm for genetic cancer risk assessment, and emphasizes the importance of meaningful guidelines for cancer-preventive care for those with less common genetic findings.
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