This population-based cohort study used administrative heath care databases in Ontario, Canada, and determined that preoperative breast MRI use is associated with a significant increase in ancillary investigations, wait time to surgery, mastectomies, and contralateral prophylactic mastectomies.
This survey study found that despite improved knowledge, understanding, and satisfaction among patients who receive genetic counseling provided by a genetics clinician, as well as guidelines emphasizing genetic counseling, most US women undergoing BRCA testing do not receive this service.
This systematic review and meta-analysis of 15 randomized clinical trials (6856 patients) finds that overall survival in intermittent androgen deprivation therapy for prostate cancer was not inferior to continuous therapy, and some quality-of-life criteria seemed improved with intermittent therapy.
This international, multicenter, phase 2b, open-label, randomized study evaluated the efficacy and safety of treatment with aldoxorubicin vs doxorubicin in patients with previously untreated locally advanced, unresectable, or metastatic soft-tissue sarcoma.
This systematic review and meta-analysis identifies contemporary occupations associated with increased incidence of risk of bladder cancer risk; workers with aromatic amine exposure have the highest incidence, while those exposed to PAHs and heavy metals have the greatest mortality.
This cost-effectiveness analysis of the SQUIRE trial findings and others evaluates incremental costs and patient life expectancies associated with adding necitumumab to standard chemotherapy as first-line treatment of metastatic squamous cell lung cancer.
This analysis and comparison of cancer treatment outcomes gleaned from 2 types of database records, those including and those not including staging information, finds that records without staging data might be adequate to accurately measure, at the hospital level, cancer survival outcomes.
This systematic review uses data from multiple medical databases and other sources to identify that sequential anthracycline-cyclophosphamide and taxane is likely the most effective adjuvant therapy for early-stage breast cancer.
This genetic sequencing study investigated whether endometrial cancers with polymerase e mutations and microsatellite instability had increased neoantigen load, more tumor-infiltrating lymphocytes, and higher expression of PD-1 and PD-L1 than endometrial cancers without these characteristics.
This review examines growing evidence that radiation therapy targeted to the tumor can convert it into an in situ tumor vaccine by inducing release of antigens during cancer cell death in association with proinflammatory signals that trigger the innate immune system to activate tumor-specific T cells.
This systematic review finds that few clinical trials in metastatic non–small-cell lung cancer report hospitalization information, but among those that do, hospitalization rates are consistently lower than in real world reports of similar patients undergoing similar therapies.
A woman in her 50s with intermittent epigastric pain, palpitations, and hot flashes had multiple intramyocardial masses involving the left ventricle, aortopulmonary window lymphadenopathy, and moderate pericardial effusion. What is your diagnosis?
A man in his 20s had a large right supraclavicular lymph node, extensive mediastinal lymphadenopathy, a large extracardiac mass abutting the left atrium, hepatomegaly, and multiple splenic lesions. What is your diagnosis?
This Viewpoint discusses management of the primary tumor in asymptomatic patients with colorectal cancer.
This viewpoint argues that drugstores, as providers of health care items and services, should be required by public pressure or legislative action to stop selling tobacco products, which harm people when used as indicated.
This Viewpoint discusses whether a broad genetic testing program for BRCA1/2 is realistic in terms of the relative value and costs of such a program.
This Viewpoint details the importance of gathering evidence before clinically using unproven but financially attractive local therapies to treat oligometastatic non–small-cell lung cancer.
Academic cancer centers play a vital role in cancer care in an increasingly cost-sensitive health care market, and proponents must emphasize the value-based clinical, research, and business contributions these centers can make to the eradication of cancer.
This commentary argues that while cutaneous adverse effects are associated with better outcomes among patients undergoing treatment with pembrolizumab, further analysis is required to determine whether nonvitiligo cutaneous adverse effects contribute to the observed outcome.