The NEfERT-T randomized clinical trial seeks to determine whether neratinib plus paclitaxel improves progression-free survival compared with trastuzumab plus paclitaxel in the first-line treatment of recurrent and/or metastatic ERBB2-positive breast cancer in a cohort of 479 women.
This molecular pathology study characterizes patterns of genetic alterations in phosphatidylinositol-3-kinase pathway components in solid tumor specimens that point toward opportunities for targeted therapy.
This cancer epidemiology study uses National Cancer Data Base data to characterize trends in use of postoperative radiotherapy for children ages 3 to 8 years with medulloblastoma, and clinical variables associated with treatment and survival.
This follow-up of a randomized clinical trial compares patient-reported outcomes between patients randomized to receive unrelated donor bone marrow or peripheral blood hematopoietic cell transplantation for hematologic cancers.
This cohort study compares the risk of cardiovascular disease in breast cancer survivors who received tamoxifen, aromatase inhibitors, both, or neither during a long-term follow-up period.
This genomic profiling study investigates the genomic mechanisms underpinning resistance to the androgen receptor antagonist enzalutamide in metastatic castration-resistant prostate cancer.
This meta-analysis summarizes the incidence of PD-1 inhibitor–related pneumonitis in patients with advanced cancer by tumor type and therapeutic regimen.
This study uses SEER data to compare trends in incidence of oropharyngeal cancer, tobacco-related cancers, and HPV-related anal cancer in elderly patients between 2000 and 2012.
This Danish nationwide cohort study evaluates the treatment-specific risks for second malignant neoplasms and death in patients with testicular germ cell cancer treated with current standard regimens.
This study uses CMS’s Open Payments Database data to describe the prevalence of financial conflicts of interest among authors of recent National Comprehensive Cancer Network guidelines.
This study of American Society of Clinical Oncology (ASCO) 2014-15 meeting videos characterizes the word count of financial conflict of interest disclosures appearing in slide presentations in response to a policy requiring the disclosure.
This survey study explores whether and how women with newly diagnosed breast cancer use online communication during the cancer treatment decision-making process.
This study examines whether B cells in patients with chronic lymphocytic leukemia receiving ibrutinib can mount a humoral immune response to seasonal influenza vaccination.
This cancer epidemiology study uses SEER database data to examine whether early-stage prostate cancer incidence rates continued their 2011 to 2012 decline in 2013.
This perspective discusses the advent of medical imaging as a data source for precision management of patients with cancer through integration of automated imaging phenotype and cancer genotype.
This clinical evidence synopsis summarizes a Cochrane systematic review evaluating the effect of nonplatinum chemotherapy vs a platinum-based combination and a nonplatinum single-agent vs a nonplatinum combination in patients older than 70 years with advanced non–small-cell lung cancer.
This Clinical Evidence Synopsis summarizes a recent Cochrane review update on interventions for high-grade vulvar intraepithelial neoplasia.
A 69-year-old man with a history of relapsed acute myeloid leukemia monocytic type presented with intermittent fever and fatigue 2 months after allogeneic stem cell transplantation; home medications included acyclovir, fluconazole, and cyclosporine. What is your diagnosis?
A 67-year-old woman with peripheral T-cell lymphoma after an allogeneic stem cell transplant on empirical broad-spectrum antibiotics for dyspnea and bilateral CXR opacities develops respiratory failure and diffuse ground-glass opacities on CT scan. What would you do next?
This Viewpoint argues in favor of a role for intermittent androgen deprivation therapy for management of men with prostate cancer.
This Viewpoint argues against a continued role for intermittent androgen-deprivation therapy in the management of men with prostate cancer.
This Viewpoint highlights recent findings in the treatment of central nervous system tumors.
This Viewpoint highlights recent study findings about the treatment of gastrointestinal (colorectal) cancer.
This Viewpoint compares the advantages and disadvantages of x-ray, proton, and heavy-ion therapy in cancer treatment, and the future of heavy-ion therapy in the United States.
This commentary discusses a trial published in JAMA that compared the effects of chest tube size and analgesia types on pain and efficacy of pleurodesis for management of malignant pleural effusion.