This phase 2, open-label, single-arm study investigates the efficacy of first-line erlotinib therapy in patients with non–small-cell lung cancer with activating EGFR mutations and the use of erlotinib therapy after disease progression.
This cohort study identifies 2237 patients with non–small-cell lung cancer and examines the association between young age at diagnosis and targetable genomic alterations and prognosis.
This observational, population-based cohort study monitors time to chemotherapy postsurgery in subgroups of patients with breast cancer and hypothesizes that delaying initiation of adjuvant chemotherapy is associated with adverse outcomes.
This study of 2 population-based databases of breast cancer from SEER-Medicare and the National Cancer Database compares time to surgery with overall and disease-specific survival.
This nested case-control study of patients in the Utah Cancer Registry who received a diagnosis of cancer of unknown primary site between 1980 and 2010 quantifies the risk of cancer by site in first- and second-degree relatives and first cousins of these individuals.
This study of patients allocated to the control arm of the STAMPEDE Trial explored the survival and the effect on survival of radiotherapy by nodal involvement in high-risk, hormone-naive men with newly diagnosed nonmetastatic prostate cancer starting long-term hormone therapy for the first time.
This study uses data from a trial comparing doses of radiation therapy for non–small-cell lung cancer to compare quality of life measures in patients given high vs low radiation doses.
This cohort study of 686 women with ovarian carcinoma to investigates whether PPMID mutations reflect an underlying cancer predisposition or consequence of cancer therapy.
This Research Letter determines whether prospective therapeutic intent, follow-up time, and late toxic events are underreported in multimodality treatment phase 1 trials.
This Research Letter reports 3 cases of chromosome-positive chronic myelogenous leukemia (CML) following therapy for germ-cell tumors and poses questions regarding the connection of etoposide and cisplatin-containing combination chemotherapy and secondary CML.
This study highlights the usefulness of agreement on disease-specific hashtags for effective online communication about cancer care.
This case series and review presents examples of patients who harbor pathogenic mutations in multiple inherited cancer genes and describes previously published examples to illustrate the complex genotype-phenotype relationships in these cases.
A man in his 60s with hypertension, hyperlipidemia, and obesity presented with severe, constant bilateral lower extremity pain along with predominantly distal purplish discoloration of both feet. What is your diagnosis?
This Viewpoint discusses the importance of precision medicine for low- and middle-income countries, as well as ways it might be implemented.
This Viewpoint discusses how the Drug Quality and Security Act has prohibited a beneficial practice of cancer drug reuse and proposes ways to solve this problem while still protecting consumers.
This Viewpoint discusses the need for oncologist involvement in developing clinical pathways for cancer care.
This commentary describes the findings of a study of long-term survival in patients with pancreatic cancer and calls for more research to help identify patients with the potential for long-term survival after pancreatic cancer resection.
Overtreatment of low grade ductal carcinoma in situ
This case series evaluates the use of integrative clinical sequencing and genetic counseling in the assessment and treatment of children and young adults with cancer.
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