This study describes the use of BRCA testing and evaluates how concerns about genetic risk and use of genetic information affect subsequent treatment decisions in young women with breast cancer.
This study compares the use of digital mammography with digital breast tomosynthesis for breast cancer screening and assesses the outcomes in a population as well as at individual levels in patients from an urban, academic breast center.
This analysis of 82 Oncologic Drugs Advisory Committee (ODAC) meeting transcripts explores the association between ODAC recommendations, ODAC members’ financial conflicts of interest, and approval of new oncologic drugs by the US Food and Drug Administration.
This meta-analysis of 36 randomized clinical trials and cohort studies of 5768 patients with HER2-positive breast cancer investigates the association between pathologic complete response to therapy and time to recurrence and death.
This population-based study examines the potential benefits of aspirin use for prevention of overall cancer and specific cancers in 2 US population cohorts of health care professionals from 1980 to 2012.
This analysis of 1800 clinical trials in advanced solid tumors identifies circumstances in which a high objective response rate is associated with regulatory approval and therefore might be an appropriate end point for definitive single-arm studies of anticancer therapies.
This single-center study assessed the association of body composition with survival and locoregional control in a population of patients undergoing radiotherapy for head and neck squamous cell carcinoma.
This case series reviews the long-term use of romidepsin in patients with cutaneous T-cell lymphoma who received a maintenance dose-sparing regimen.
Effective use of Twitter might be one way to communicate with the public about cancer clinical trials and increase awareness and enrollment.
This study examines the association of human papillomavirus genotype with survival in patients with head and neck squamous cell carcinoma.
This study explores the impact of BIM polymorphism on treatment outcome of patients with advanced adenocarcinoma, comparing those who experienced primary resistance with those who had partial response after treatment with epidermal growth factor receptor tyrosine kinase inhibitors.
This narrative review explores methods and potential limitations of different natural language processing strategies to foster collaborative efforts that can lead to advancements in cancer care.
This systematic review discusses current advancements in understanding the prognostic and predictive value of KRAS in non–small-cell lung cancer and attempts to explain the treatment advancements in both preclinical and clinical settings.
A white woman in her 60s with a medical history of multiple joint replacements related to osteoarthritis presented with left leg pain; a plain radiograph of the left femur showed a 15-cm area of moderate destruction in the proximal femoral shaft extending distally from the level of the lesser trochanter. What is your diagnosis?
This Viewpoint argues against universal tumor sequencing.
This Viewpoint argues for universal tumor sequencing.
This Viewpoint discusses the optimal duration of imatinib as adjuvant therapy for gastrointestinal stromal tumors.
This commentary argues on behalf of alternating electromagnetic fields, or tumor treating fields (TTFs), to treat certain cancers and states that TTFs may eventually be integrated into management paradigms for a variety of tumors and clinical scenarios