This case-control study evaluates pathogenic variants in panel genes tested in women with breast cancer.
This study examines the association among mismatch repair deficiency, microsatellite instability, and survival in patients with resectable gastroesophageal cancer randomized to surgery alone or perioperative chemotherapy.
This longitudinal registry study assesses the clinical spectra and age-related penetrance in individuals with pheochromocytomas and paragangliomas and mutations in the SDHA, TMEM127, MAX, and SDHAF2 genes.
This survey evaluates pediatric patients’ and parents’ perceptions of symptom burden during early cancer treatment and assesses their attitudes toward early integration of palliative care in pediatric oncology.
This randomized clinical trial compares the effects of metronomic chemotherapy on progression-free survival vs placebo in pediatric patients with primary extracranial, nonhematopoietic solid malignant tumors that progress after at least 2 lines of chemotherapy.
This population-based, case-control, cohort study uses data from the Breast Cancer Surveillance Consortium to assess risk factors associated with breast cancer in premenopausal and postmenopausal women.
This phase 2 trial assesses the effect of neoadjuvant chemotherapy followed by surgery on survival in patients with metastatic gastric and gastroesophageal junction cancer.
This study analyzes how patient preferences and burden of disease can be incorporated into randomized clinical trials in oncology using Bayesian decision analysis and the impact that these factors have on statistical thresholds for drug approval.
This phase 1/2 open-label study reports a planned update of the safety and efficacy of durvalumab in patients with locally advanced/metastatic urothelial carcinoma who had progressed on, were ineligible for, or refused prior chemotherapy.
This case-control study analyzed the entire coding region of the FANCM gene to find its association with breast and ovarian cancer risk.
This updated analysis of a subset in the ASSURE clinical trial examines the disease-free survival and overall survival of high-risk patients with clear cell renal cancer treated with sunitinib, sorafenib, or placebo.
This medical record review assesses the clinical and radiologic responses to cladribine for the treatment of adults with Erdheim-Chester disease.
This study examines whether low-dose computed tomography screening for lung cancer increased following the United States Preventive Services Task Force recommendations.
This study examines the effectiveness of interactive telephone calls vs automated short message service on improving adherence to fecal immunochemical test screening compared with usual care.
This Special Communication provides consensus recommendations for a risk-adapted approach to treatment of Waldenström macroglobulinemia.
This review examines androgen receptor (AR)-related pathways, specific AR-targeted therapies, and the development of predictive biomarkers to stratify patients by likelihood of response to AR-targeted therapies.
This Clinical Evidence Synopsis summarizes 3 randomized clinical trials that compare whole-brain radiotherapy with highly active targeted therapies in patients with non–small-cell lung cancer with brain metastases.
A man in his 40s with newly diagnosed acute myelogenous leukemia arising from myelodysplasia presented with fever, cough, abdominal pain, difficulty swallowing, and 1 month of neutropenia. What is your diagnosis?
This Viewpoint describes the high cost of new cancer therapies, making comparisons to the early years of the AIDS epidemic, when many patients in low-resource countries died because of the initial high cost of HIV medications.
This Viewpoint discusses the uncertain evidence for second-line treatment of pleural malignant mesothelioma.
This Viewpoint questions the use of anthracyclines in the treatment of gastroesophageal cancers.
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