This secondary analysis of a randomized clinical trial examines the association between driver alterations and the risk of mutations and prognosis in women with postmenopausal hormone receptor–positive, HER2-negative breast cancer.
This phase 2 clinical trial investigates the safety and efficacy of BIND-014, a docetaxel-containing nanoparticle targeting prostate-specific membrane antigen, for treating patients with metastatic castration-resistant prostate cancer.
This cohort analysis examines the association between self-reported exercise and change in exercise and mortality in adult survivors of childhood cancer.
This randomized clinical trial tests the effect of consultation with a lay health worker on documentation of goals of care and health care use, costs, and satisfaction among patients with advanced-stage or recurrent cancer at a Veterans Affairs medical center.
This randomized clinical trial compares treatment with everolimus plus exemestane vs everolimus or capecitabine monotherapy for estrogen receptor-positive, HER2-negative advanced breast cancer.
This cohort study compares overall survival, treatment adherence, and patient characteristics among patients with cancer receiving conventional cancer treatment with vs without complementary medicine.
This exploratory recursive partitioning analysis modeled associations between prespecified covariates and survival outcomes using pooled data from 4 randomized clinical trials of adult patients with BRAF V600–mutated metastatic melanoma treated with dacarbazine, vemurafenib, or cobimetinib plus vemurafenib.
This systematic review and network meta-analysis analyzes and compares different maintenance regimens for treating patients with newly diagnosed multiple myeloma and associated progression-free and overall survival.
This secondary analysis of the Women’s Health Initiative randomized clinical trial investigates the association of a low-fat dietary pattern vs a usual diet comparison with overall survival among women with breast cancer.
This study examines the use of next-generation sequencing for identification of potentially actionable alterations in patients with soft-tissue sarcoma.
This secondary analysis of the NRG Oncology/RTOG 0424 randomized clinical trial examines the proportion of patients with MGMT promoter methylation and its association with survival outcomes in high-risk glioma treated with radiotherapy and temozolomide.
This cohort study using data from the US National Cancer Database assesses the patterns of use and the effectiveness of adjuvant endocrine therapy for hormone receptor–positive breast cancer in men.
This validation study investigates the use of circulating protein biomarkers to improve lung cancer risk assessment and eligibility criteria for screening with low-dose computed tomography.
This analysis of interviews with Dutch oncologists investigates the outcomes of second-opinion requests for physician-patient and physician-colleague relationships.
This analysis investigates the prevalence of financial relationships between oncologist authors of clinical drug trials and the pharmaceutical industry and how often such financial interests are unreported.
This narrative review discusses the pathophysiology of adult acute lymphoblastic leukemia and recent progress in the development of personalized therapies.
An adolescent girl presented with a painless mass in the right thigh and high uptake of fluorodeoxyglucose on positron emission tomography. What is your diagnosis?
This Viewpoint discusses the Centers for Disease Control and Prevention guidelines for prescribing opioids for chronic pain and how they may cause confusion for oncology clinicians.
This Viewpoint discusses how expert review of breast pathology in borderline lesions may offer the opportunity to reduce overdiagnosis and overtreatment of breast cancer.
This Viewpoint examines the ethics of informed consent and test result disclosure associated with direct-to-consumer genetic testing for hereditary cancer susceptibility.
This commentary discusses a cohort study of patients with non–small cell lung cancer published in JAMA that compares clinical outcomes following broad-based genomic sequencing vs routine testing for EGFR mutations and/or ALK mutations.
This article discusses the bravery of an elderly cancer patient from Finland who had sisu, a Finnish word to describe ferocity and tenacity.