This cost-effectiveness study uses a life-table model of a hypothetical cohort of 364 500 women to evaluate the cost-effectiveness and benefit to harm ratio of risk-stratified screening for breast cancer.
This survey study examines the propensity of surgeons to use axillary lymph node biopsy alone for axillary management in women with early-stage breast cancer undergoing breast-conserving surgery.
This cohort study uses Surveillance, Epidemiology, and End Results data to determine high- and low-risk periods for 68 cancer types that could define when survivorship care might best be overseen by oncologists and when to transition to primary care physicians.
This cohort study examines mechanisms of acquired resistance to osimertinib in patients with non–small cell lung cancer and the associated clinical implications.
This cross-sectional analysis compares downstaging, responses, and survival outcomes in patients with muscle-invasive bladder cancer treated with cystectomy who underwent neoadjuvant chemotherapy with gemcitabine with cisplatin, gemcitabine with carboplatin, or dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin.
This multicenter cohort study investigates whether hyperprogressive disease is observed in patients with advanced non–small cell lung cancer treated with programmed cell death 1 and programmed cell death ligand 1 inhibitors compared with single-agent chemotherapy.
This systematic analysis evaluates the cancer burden over time at the global and national levels measured in incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years.
This randomized clinical trial examines the efficacy of anlotinib compared with placebo as a third-line or further therapy on overall survival of adult patients with advanced non–small cell lung cancer.
This cohort study of patients from the 5 Nordic countries examines whether gastroesophageal antireflux surgery is associated with decreased risk of esophageal adenocarcinoma and whether surgically and medically treated patients experience different outcomes.
This pooled analysis of individual patient data investigates the association of body mass index with subsequent breast cancer risk, in particular by age, attained age, risk factors for breast cancer, and tumor characteristics, in premenopausal women.
This post hoc analysis of the Vitamin D Assessment randomized clinical trial assesses the association of monthly high-dose vitamin D supplementation vs placebo on cancer risk among New Zealand adults.
This randomized clinical trial compares outcomes of standard chemotherapy and cetuximab combination therapy with vs without motolimod in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.
This gene-sequencing study identifies and quantifies clonal hematopoiesis–related mutations in patients with solid-tumor cancers using matched tumor-blood sequencing and examines the proportion that would be misattributed to the tumor based on tumor-only sequencing (unmatched analysis).
This biomarker study estimates the diversity of T-cell populations in the tumor microenvironment by assessing messenger RNA expression of the T-cell receptor β chain variable gene from RNA sequencing data of pretreatment biopsies of women with HER2-positive breast cancer in the Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimisation (NeoALTTO) trial.
This study uses the European Society of Medical Oncology Magnitude of Clinical Benefit Scale to evaluate the clinical benefit of anticancer drugs that gained approval by the US Food and Drug Administration based on single-arm rather than randomized clinical trials.
This population-based study compares opioid use in patients with non–small cell lung cancer who underwent open resection vs video-assisted thoracoscopic surgery.
This survey study evaluates the presence of erectile dysfunction in men who had experienced cancer during childhood.
This cohort study examines the association of androgen deprivation therapy with dementia in male veterans with prostate cancer who receive definitive radiotherapy.
This Special Communication discusses consensus recommendations regarding follow-up of fully resected, well-differentiated, or moderately differentiated gastroenteropancreatic neuroendocrine tumors.
This Insights discusses management strategies for liver neuroendocrine tumors using the most recent therapeutic options.
A 3-year-old girl with B-cell acute lymphoblastic leukemia and no known skin trauma presented with an asymptomatic skin lesion with violaceous to black plaque, a central hemorrhagic bulla, and surrounding hyperemia on the left lower back. What is your diagnosis?
This Viewpoint assesses the use of low-dose bisphosphonates to reduce the risks of bone metastases and mortality in postmenopausal patients with early breast cancer.
This Viewpoint examines how a more patient-focused payment model could improve the success of payment reforms that encourage higher-value care.
This Viewpoint discusses whether the changes in the health care marketplace, the evolution of precision medicine, and the uniqueness of drug development and labeling for cancer diagnoses make the Orphan Drug Act less necessary and less relevant today than at its inception.
This essay describes the process of coming to an understanding of grief following the death of a family member who had cancer.
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