This cohort study examines whether an assay for the nuclear-localized androgen receptor splice variant 7 protein in circulating tumor cells can be used to estimate overall survival among patients with metastatic castration-resistant prostate cancer treated with taxanes vs androgen receptor signaling inhibitors.
This secondary analysis of tumor specimens collected for the LUX-Lung 8 randomized clinical trial assesses whether ERBB gene mutations of family members were associated with outcomes among patients with lung squamous cell carcinoma randomized to treatment with afatinib or erlotinib.
This randomized clinical trial evaluates the efficacy and safety of adjuvant trastuzumab continued beyond chemotherapy for a duration of 9 weeks vs 1 year in women with HER2-positive early breast cancer treated with up-front chemotherapy containing a taxane and trastuzumab.
This single-arm, open-label trial evaluates the safety and efficacy of the anti–epidermal growth factor receptor antibody panitumumab plus neoadjuvant chemotherapy (nab-paclitaxel and carboplatin followed by fluorouracil, epirubicin, and cyclophosphamide) in patients with primary HER2-negative inflammatory breast cancer.
This clinical trial investigates the maximum tolerated dosage of tucatinib combined with ado-trastuzumab emtansine in the treatment of patients with ERBB2/HER2-positive metastatic breast cancer with and without brain metastases.
This systematic analysis reports incidence, mortality, and disability-adjusted life-year (DALY) estimates from the Global Burden of Disease 2016 study to characterize the burden of multiple myeloma and the availability of effective therapies for 21 world regions and 195 countries and territories from 1990 to 2016.
This cohort study examines the prevalence of germline mutations in patients with known renal cell carcinoma predisposition genes and other cancer-associated genes and identifies clinical and pathologic factors associated with germline mutations.
This tumor database study examines the prevalence of PDL1 amplification and its utility as a response biomarker to PD-1/PD-L1 blockade in solid tumors.
This registry-based study compares survival in patients with acute myelogenous leukemia who have undergone a second allogeneic hematopoietic cell transplant vs donor lymphocyte infusion after relapse.
Using 14 years of data from the US Central Brain Tumor Registry and the Surveillance, Epidemiology, and End Results registries, this study examines the incidence and survival rates of glioma and its subtypes among 4 racial or ethnic groups.
This cohort study reports the long-term accuracy of the Tyler-Cuzick model combined with breast density in assessment of risk for breast cancer among women in a state registry.
This analysis of data from a single-arm clinical trial investigates whether stereotactic body radiation therapy delivered on an outpatient basis for patients with operable early-stage lung cancer is associated with primary tumor control, survival, adverse events, and the need for surgical resection.
This preplanned interim analysis of a single-arm clinical trial evaluates the efficacy and safety of avelumab as first-line treatment for patients with distant metastatic Merkel cell carcinoma.
This observational study examines the activity of anthracycline-based regimens, gemcitabine-based regimens, and pazopanib in patients with advanced epithelioid sarcoma.
This study evaluates 5-year data from the NRG Oncology RTOG 0236 trial on the effects of sterotactic body radiation therapy in patients with inoperable stage I non–small cell lung cancer.
This cohort study investigates overall survival among patients with newly diagnosed metastatic cervical cancer who received chemotherapy alone compared with those who received chemotherapy and pelvic radiation therapy.
This population-based study assesses demographic characteristics, CT scan findings, and lung cancer detection in minority populations compared with outcomes from the National Lung Screening Trial.
This case study compares diagnosis codes with pathology reports for patients diagnosed with sarcoma to assess the accuracy of disease coding at a health care center.
This review discusses the problems associated with funding for development of drug therapy to treat cancer in children and proposes a financial model to address the challenges.
A man in his 50s with a medical history of myelodysplastic syndrome refractory anemia with excess blasts presented with a 2-month history of nonpruritic infiltrative skin lesions on the left upper chest. What is your diagnosis?
This Viewpoint argues in favor of using neoadjuvant chemotherapy for the treatment of localized high-risk soft-tissue sarcoma of the extremities and trunk.
This Viewpoint argues against using neoadjuvant chemotherapy for the treatment of localized high-risk soft-tissue sarcoma of the extremities and trunk.
This Viewpoint discusses the positive and negative implications of the US national coverage determination for reimbursement for next-generation sequencing by the Centers for Medicare & Medicaid Services.
This Patient Page provides information on neutropenia, a condition associated with having an abnormally low number of neutrophils in the blood resulting in increased risk of infection.
This article discusses a community support group for patients with neuroendocrine tumors, and learning to build trust as a team.
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