This secondary analysis of the Women’s Health Initiative randomized clinical trial and observational study cohort investigates the association between body fat and breast cancer risk in postmenopausal women with normal body mass index.
This randomized clinical trial examines whether patients treated with sunitinib before cytoreductive nephrectomy have better outcomes than patients immediately treated with cytoreductive nephrectomy and then given sunitinib.
This study assesses whether plasma-based next-generation sequencing was associated with improved mutation detection and enhanced delivery of personalized therapy in a real-world clinical setting of patients with non–small cell lung cancer.
This prospective cohort study evaluates the 5-year risk of cervical precancer following p16/ki-67 dual-stain triage of HPV-positive women.
This follow-up of a randomized phase 3 trial compares the 3-year survival with nivolumab vs that with dacarbazine in patients with previously untreated BRAF wild-type advanced melanoma.
This phase 2 randomized clinical trial compare the efficacy and toxicity profiles of durvalumab monotherapy and tremelimumab monotherapy against a combination of both in patients with recurrent or metastatic head and neck squamous cell carcinoma with low or no expression of programmed death ligand 1.
This prospective study examines the diagnostic accuracy of a multigene genomic classifier test for diagnosis of benign disease or cancer in thyroid nodules with indeterminate cytology.
This cohort study investigates whether treatment of Gleason score 9-10 prostate cancer with radical prostatectomy, adjuvant external beam radiotherapy, and androgen deprivation therapy (termed MaxRP) vs external beam radiotherapy, brachytherapy, and androgen deprivation therapy (termed MaxRT) was associated with prostate cancer–specific mortality and all-cause mortality risk.
This cohort study investigates the association between radiation doses in the parotid glands and self-reported xerostomia among adults treated with whole-brain radiation therapy.
This cohort study examines patient data in the European Society for Blood and Marrow Transplantation Registry for causes of death, risk factors, and overall survival rates among patients who received a second cancer diagnosis after being treated with stem cell transplant.
This Markov model study assesses the cost-effectiveness of capecitabine and bevacizumab maintenance therapy after induction chemotherapy for treatment of metastatic colorectal cancer.
This phase 1b clinical trial evaluates the dose response and safety of alpelisib plus fulvestrant treatment in women with advanced breast cancer.
This exploratory secondary analysis of a randomized clinical trial evaluated local control of brain metastases among patients treated with stereotactic radiosurgery vs surgical resection in the European Organization for the Research and Treatment of Cancer 22952-26001 phase 3 trial.
This study uses clinical sequencing data to examine the association between JAK2-V617F detected by solid tumor sequencing and mutations in the tumor, clonal hematopoiesis of indeterminate potential, or myeloproliferative neoplasms.
This population-based study describes the incidence, latency period, and outcomes of radiotherapy-associated angiosarcoma among patients with breast cancer from the Netherlands Cancer Registry.
This narrative review discusses current understanding of alveolar soft-part sarcomas with a focus on new findings and treatments.
In this article the authors review the shift toward earlier use of therapeutic treatments in the course of advanced prostate cancer
An HIV-positive man in his 30s being treated with pembrolizumab for metastatic programmed cell death ligand 1–positive squamous non–small cell lung cancer presents with pruritic, mildly painful, hyperpigmented papules and plaques on both feet. What is your diagnosis?
This Viewpoint analyzes data on the thrombotic risk associated with cyclin-dependent kinase inhibitors and notes the need for additional research on the thrombotic risk of these drugs, the influence of combined drug therapy on thrombotic risk, and patient selection.
This Viewpoint discusses the initials results of the NCI-MATCH trial, a phase 2 study that seeks to determine whether targeted therapies for specific gene mutations will lead to objective responses agnostic to the primary cancer type.
This Viewpoint uses results of randomized clinical trials to explore whether the use of abiraterone acetate plus prednisone is a cost-effective and appropriate treatment option for patients with nonmetastatic castration-resistant prostate cancer.
This article examines the tradition of bell ringing as a method of celebrating the completion of cancer treatment.
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