This case series study assesses the prevalence of microsatellite instability–high or mismatch repair–deficient prostate cancer and the clinical benefit of immune checkpoint blockade with anti–PD-1/PD-L1 therapy in this molecularly defined population.
This systematic review and meta-analysis examines randomized clinical trials to assess the safety and efficacy of medications used for patients with gastrointestinal and pancreatic neuroendocrine tumors.
This cost-effectiveness analysis compares nivolumab plus ipilimumab vs sunitinib to examine whether the drug combination is cost-effective from a US payer perspective as a first-line treatment for intermediate- and poor-risk patients with metastatic renal cell carcinoma.
This cohort study describes prevalence rates of infection with hepatitis B virus, hepatitis C virus, and HIV among patients with newly diagnosed cancer in academic and community oncology practices.
This randomized clinical trial of patients with stage I gastric cancer examines whether long-term survival among patients undergoing laparoscopic distal gastrectomy is noninferior to that among patients undergoing open distal gastrectomy.
This case-control study evaluates the enrichment of germline pathogenic variants in the mendelian cancer predisposition DNA repair genes in patients with testicular germ cell tumors compared with healthy controls.
This cross-sectional study assesses the frequency and distribution of positive germline variants in patients with prostate cancer and evaluates the usefulness of current practice guidelines in recognizing individuals with prostate cancer who would benefit from diagnostic genetic testing.
This systematic review and meta-analysis examine randomized clinical trials to assess whether immunotherapy treatments for advanced cancer are less effective in female patients.
This nationwide, population-based cohort-cohort study of compares the temporal pattern of hospitalizations for medically verified incident somatic disease between cancer survivors and cancer-free people.
This case series of patients with rectal cancer compares outcomes between those who had a clinical complete response to neoadjuvant therapy and agreed to a watch-and-wait strategy and those who underwent total mesorectal excision and had a pathologic complete response at resection.
This phase 2, open-label, interventional study examined the safety and efficacy of pembrolizumab for patients with advanced, metastatic esophageal carcinoma that has progressed after 2 or more lines of systemic therapy.
This cohort study investigates possible mechanisms underlying primary resistance to immune checkpoint inhibitors of metastatic colorectal cancers displaying microsatellite instability or mismatch repair deficiency.
This study assesses the outcomes of single-patient use of the US Food and Drug Administration Expanded Access program.
This narrative review describes the parallels and differences between prostate cancer and thyroid cancer regarding screening, diagnosis, risk stratification, and considerations for active surveillance.
This article describes an approach to active surveillance and treatment of desmoid tumor (aggressive fibromatosis).
A white woman in her 70s with Alzheimer disease presented with a high hemoglobin level and red blood cell count as well as erythematous macular eruption over the trunk and limbs. What is your diagnosis?
This Viewpoint highlights the importance of potential bias in patient-reported outcomes in open-label cancer trials and points to areas of research that could address this challenge.
This Viewpoint suggests that advance care planning discussions can be initiated during transitions in care from cancer clinical trials.
This Viewpoint evaluates new transparency policies in cancer research and drug development.
This essay describes one physician’s approach to patients with cancer who question their initial decision to forgo conventional definitive treatment.
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