Two parallel phase 2 nonrandomized clinical trials examine the therapeutic effectiveness of the poly–(adenosine diphosphate–ripose) polymerase inhibitor olaparib for patients with pancreatic cancer with DNA damage repair other than germline BRCA variants.
This randomized clinical trial compares toxic effects, prostate-specific antigen responses, and quality-of-life end points of single-dose radiotherapy vs stereotactic body radiotherapy in patients with prostate cancer.
This randomized clinical trial assesses the efficacy and safety of tislelizumab plus chemotherapy vs chemotherapy alone as first-line treatment for patients with advanced squamous non–small-cell lung cancer.
This randomized clinical trial explores the effectiveness of electroacupuncture and auricular acupuncture compared with usual care for chronic musculoskeletal pain in cancer survivors.
This cohort study describes contemporary trends in oncology randomized clinical trials (RCTs) and compares these findings with earlier eras of RCT design and output.
This cohort study examines the use of hypofractionated ablative radiation therapy for patients with locally advanced pancreatic cancer treated with a novel radiation planning and delivery technique.
This cohort study examines the performance of a universal definition of high tumor mutational burden in an independent cohort of patients with solid tumors treated with immune checkpoint inhibitors.
This cohort study determines the incidence, time course, spectrum, and associations of chronic immune-related adverse events with adjuvant anti–programmed cell death 1 treatment.
This cohort study examines treatment with immune checkpoint inhibitors for patients with metastatic renal cell carcinoma.
This pharmacovigilance study uses data from the World Health Organization database of adverse drug reactions to examine the association of antiangiogenic drugs with artery dissections or aneurysms among patients receiving antiangiogenic drugs for the treatment of cancer.
This review addresses the increasing knowledge on tumor biology and neuroendocrine differentiation of other malignant tumors, the current standard of care, and developments in new treatments for small cell lung cancer and extrapulmonary neuroendocrine carcinomas.
A man in his 60s with chronic lymphocytic leukemia presents with purpuric rash on his scalp. What is your diagnosis?
This Viewpoint advocates for a reevaluation of the use of temozolomide for patients with MGMTp unmethylated glioblastomas during the COVID-19 pandemic.
This Viewpoint explores the application of the results of the ADAURA trial.
This Viewpoint discusses the benefits of using adjuvant targeted therapy in earlier stages of cancer based on multiple randomized trials with promising results.
In this essay, an oncology fellow describes how his conversations with patients with terminal cancer and their families have changed regarding travel and gathering restrictions during the COVID-19 pandemic
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