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May 25, 2023
Original Investigation

Clinical Activity of Olvimulogene Nanivacirepvec–Primed Immunochemotherapy in Heavily Pretreated Patients With Platinum-Resistant or Platinum-Refractory Ovarian Cancer: The Nonrandomized Phase 2 VIRO-15 Clinical Trial

Abstract Full Text
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JAMA Oncol. Published online May 25, 2023. doi:10.1001/jamaoncol.2023.1007

This nonrandomized phase 2 clinical trial examines the clinical activity of Olvi-Vec oncolytic immunotherapy and subsequent platinum-doublet chemotherapy with or without bevacizumab in women with platinum-resistant or -refractory ovarian cancers.

Association of Second-generation Antiandrogens With Cognitive and Functional Toxic Effects in Randomized Clinical Trials: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA Oncol. Published online May 25, 2023. doi:10.1001/jamaoncol.2023.0998

This systematic review and meta-analysis examines the risk of toxic effects associated with second-generation antiandrogens administered to men with prostate cancer in randomized clinical trials.

Editorial

Missing, Inconsistent, and Other—A Call to Improve Transgender Representation in Oncology Research

Abstract Full Text
JAMA Oncol. Published online May 25, 2023. doi:10.1001/jamaoncol.2023.1344

Vaccinia (Smallpox) for the Treatment of Ovarian Cancer—Turning an Old Foe Into a Friend?

Abstract Full Text
JAMA Oncol. Published online May 25, 2023. doi:10.1001/jamaoncol.2023.0983
Invited Commentary

Balancing Treatment Benefits of Androgen-Receptor Signal Inhibitors and Quality of Life in Patients With Prostate Cancer

Abstract Full Text
JAMA Oncol. Published online May 25, 2023. doi:10.1001/jamaoncol.2023.0982
Poetry and Oncology

Two Hands, One Journey

Abstract Full Text
JAMA Oncol. Published online May 25, 2023. doi:10.1001/jamaoncol.2023.1349
Comment & Response

Tucatinib Plus Trastuzumab and Capecitabine for ERBB2 (HER2)-Positive Metastatic Breast Cancer With Brain Metastases

Abstract Full Text
JAMA Oncol. Published online May 25, 2023. doi:10.1001/jamaoncol.2023.1388

Tucatinib Plus Trastuzumab and Capecitabine for ERBB2 (HER2)-Positive Metastatic Breast Cancer With Brain Metastases—Reply

Abstract Full Text
JAMA Oncol. Published online May 25, 2023. doi:10.1001/jamaoncol.2023.1391
May 18, 2023
Original Investigation

Association of MGMT Promotor Methylation With Survival in Low-grade and Anaplastic Gliomas After Alkylating Chemotherapy

Abstract Full Text
JAMA Oncol. Published online May 18, 2023. doi:10.1001/jamaoncol.2023.0990

This cohort study evaluates the association of MGMT promoter methylation for low-grade and anaplastic gliomas with chemotherapy response.

Risk of Syndrome-Associated Cancers Among First-Degree Relatives of Patients With Pancreatic Ductal Adenocarcinoma With Pathogenic or Likely Pathogenic Germline Variants

Abstract Full Text
JAMA Oncol. Published online May 18, 2023. doi:10.1001/jamaoncol.2023.0806

This case series assesses the gene-specific risk estimates of development of pancreatic ductal adenocarcinoma (PDAC) and extra-PDAC among first-degree relatives of patients with PDAC who carry pathogenic or likely pathogenic germline variants in cancer syndrome–associated genes.

Brief Report

Panitumumab Plus Trifluridine-Tipiracil as Anti–Epidermal Growth Factor Receptor Rechallenge Therapy for Refractory RAS Wild-Type Metastatic Colorectal Cancer: A Phase 2 Randomized Clinical Trial

Abstract Full Text
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JAMA Oncol. Published online May 18, 2023. doi:10.1001/jamaoncol.2023.0655

This randomized clinical trial assesses progression-free survival among patients with RAS wild-type metastatic colorectal cancer receiving panitumumab plus standard-of-care trifluridine-tipiracil as third-line therapy.

Invited Commentary

MGMT Methylation Status in Grades 2 and 3 Gliomas Is Important, but Is It Prognostic?

Abstract Full Text
JAMA Oncol. Published online May 18, 2023. doi:10.1001/jamaoncol.2023.0759
Comment & Response

External Control Arms and Data Analysis Methods in Nonrandomized Trial of Patients With Glioblastoma

Abstract Full Text
JAMA Oncol. Published online May 18, 2023. doi:10.1001/jamaoncol.2023.1066

External Control Arms and Data Analysis Methods in Nonrandomized Trial of Patients With Glioblastoma

Abstract Full Text
JAMA Oncol. Published online May 18, 2023. doi:10.1001/jamaoncol.2023.1069

External Control Arms and Data Analysis Methods in Nonrandomized Trial of Patients With Glioblastoma—Reply

Abstract Full Text
JAMA Oncol. Published online May 18, 2023. doi:10.1001/jamaoncol.2023.1072
May 15, 2023
Special Communication

American Radium Society Appropriate Use Criteria for Radiation Therapy in the Multidisciplinary Management of Thymic Carcinoma

Abstract Full Text
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JAMA Oncol. Published online May 15, 2023. doi:10.1001/jamaoncol.2023.1175

This Special Communication describes the development of expert multidisciplinary consensus guidelines on the management of common presentations of thymic carcinoma.

May 11, 2023
Original Investigation

Efficacy of Endocrine Therapy Plus Trastuzumab and Pertuzumab vs De-escalated Chemotherapy in Patients with Hormone Receptor–Positive/ERBB2-Positive Early Breast Cancer: The Neoadjuvant WSG-TP-II Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online May 11, 2023. doi:10.1001/jamaoncol.2023.0646

This randomized clinical trial aims to determine whether neoadjuvant de-escalated chemotherapy is superior to endocrine therapy, both in combination with pertuzumab and trastuzumab, in a highly heterogeneous hormone receptor–positive/ERBB2-positive early breast cancer.

Brief Report

Clinical Features and Risk Factors Associated With Multisystem Inflammatory Syndrome in Children With Cancer and COVID-19

Abstract Full Text
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JAMA Oncol. Published online May 11, 2023. doi:10.1001/jamaoncol.2023.0525

This cohort study evaluates factors associated with multisystem inflammatory syndrome in children with cancer and describes the clinical course of COVID-19 in the setting of this syndrome.

Research Letter

Trends in the Prevalence of Functional Limitations Among US Cancer Survivors, 1999-2018

Abstract Full Text
JAMA Oncol. Published online May 11, 2023. doi:10.1001/jamaoncol.2023.1180

This cross-sectional study examines trends in the prevalence of functional limitation in cancer survivors using data from the National Health Interview Survey.

Review

Adjuvant Treatments for Surgically Resected Non–Small Cell Lung Cancer Harboring EGFR Mutations: A Review

Abstract Full Text
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JAMA Oncol. Published online May 11, 2023. doi:10.1001/jamaoncol.2023.0459

This review reports current evidence on outcomes of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor treatment in patients with resectable EGFR mutation–positive non–small cell lung cancer.

Comment & Response

Evidence on Effectiveness of Immune Checkpoint Inhibitors in Patients With Advanced Esophageal Squamous Cell Carcinoma

Abstract Full Text
JAMA Oncol. Published online May 11, 2023. doi:10.1001/jamaoncol.2023.0972

Evidence on Effectiveness of Immune Checkpoint Inhibitors in Patients With Advanced Esophageal Squamous Cell Carcinoma—Reply

Abstract Full Text
JAMA Oncol. Published online May 11, 2023. doi:10.1001/jamaoncol.2023.0975
May 4, 2023
Original Investigation

Bacterial Decolonization for Prevention of Radiation Dermatitis: A Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online May 4, 2023. doi:10.1001/jamaoncol.2023.0444

This randomized clinical trial determines the efficacy of bacterial decolonization to reduce the severity of acute radiation dermatitis compared with standard of care.

Association of Food Deserts and Food Swamps With Obesity-Related Cancer Mortality in the US

Abstract Full Text
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JAMA Oncol. Published online May 4, 2023. doi:10.1001/jamaoncol.2023.0634

This cross-sectional study investigates food deserts and food swamps in US counties and their association with obesity-related cancer mortality.

Brief Report

Association of Staphylococcus aureus Colonization With Severity of Acute Radiation Dermatitis in Patients With Breast or Head and Neck Cancer

Abstract Full Text
JAMA Oncol. Published online May 4, 2023. doi:10.1001/jamaoncol.2023.0454

This cohort study assesses the association of Staphylococcus aureus colonization with acute dermatitis severity in patients with breast or head and neck cancer.

Invited Commentary

A Critical Need to Examine the Lack of Access to Healthy Quality Foods and Its Association With Cancer Mortality—A Clarion Call for Multilevel Research and Interventions

Abstract Full Text
JAMA Oncol. Published online May 4, 2023. doi:10.1001/jamaoncol.2023.0593
Comment & Response

Reporting of Immunotherapy and Biologic Therapy in the National Cancer Database

Abstract Full Text
JAMA Oncol. Published online May 4, 2023. doi:10.1001/jamaoncol.2023.0781

Reporting of Immunotherapy and Biologic Therapy in the National Cancer Database—Reply

Abstract Full Text
JAMA Oncol. Published online May 4, 2023. doi:10.1001/jamaoncol.2023.0784
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