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Year

Day

September 27, 2018
Original Investigation

Combining Immune Checkpoint Blockade and Tumor-Specific Vaccine for Patients With Incurable Human Papillomavirus 16–Related CancerA Phase 2 Clinical Trial

Abstract Full Text
JAMA Oncol. Published online September 27, 2018. doi:10.1001/jamaoncol.2018.4051

This phase 2 clinical trial examines whether the efficacy of nivolumab is amplified through treatment with ISA 101, a synthetic long-peptide human papillomavirus 16 vaccine, in patients with incurable human papillomavirus 16–positive cancer.

Risk of Hepatocellular Carcinoma in Patients Treated With Entecavir vs Tenofovir for Chronic Hepatitis BA Korean Nationwide Cohort Study

Abstract Full Text
JAMA Oncol. Published online September 27, 2018. doi:10.1001/jamaoncol.2018.4070

This cohort study uses data from the Korean National Health Insurance Service database to compare the risk of hepatocellular cancer associated with entecavir vs tenofovir disoproxil fumarate in patients receiving long-term treatment for chronic hepatitis B infection.

Editorial

Tenofovir vs Entecavir for Hepatocellular Carcinoma Prevention in Patients With Chronic Hepatitis BOne of These Things Is Not Like the Other

Abstract Full Text
JAMA Oncol. Published online September 27, 2018. doi:10.1001/jamaoncol.2018.4039
September 20, 2018
Original Investigation

Humanized 3F8 Anti-GD2 Monoclonal Antibody Dosing With Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Resistant NeuroblastomaA Phase 1 Clinical Trial

Abstract Full Text
JAMA Oncol. Published online September 20, 2018. doi:10.1001/jamaoncol.2018.4005

This phase 1 clinical trial examines the escalation and safety of humanized anti-GD2 antibody doses in combination with granulocyte-macrophage colony-stimulating factor for treating patients with high-risk neuroblastoma.

Effect of Apoyo con Cariño (Support With Caring) Trial of a Patient Navigator Intervention to Improve Palliative Care Outcomes for Latino Adults With Advanced CancerA Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online September 20, 2018. doi:10.1001/jamaoncol.2018.4014

This randomized clinical trial investigates if a culturally tailored patient navigator intervention can improve palliative care outcomes for Latino patients with advanced cancer.

Brief Report

Association of Gleason Grade With Androgen Deprivation Therapy Duration and Survival OutcomesA Systematic Review and Patient-Level Meta-analysis

Abstract Full Text
JAMA Oncol. Published online September 20, 2018. doi:10.1001/jamaoncol.2018.3732

This meta-analysis examines the association of Gleason grade with the effectiveness of androgen deprivation therapy with radiotherapy in treating patients with high-risk prostate cancer.

Review

Targeted Alpha Therapy, an Emerging Class of Cancer AgentsA Review

Abstract Full Text
JAMA Oncol. Published online September 20, 2018. doi:10.1001/jamaoncol.2018.4044

This narrative review describes targeted alpha therapy and reviews the rationale and considerations for its development and implementation as a viable treatment strategy in oncology.

September 13, 2018
Original Investigation

Total Medicare Costs Associated With Diagnosis and Treatment of Prostate Cancer in Elderly Men

Abstract Full Text
JAMA Oncol. Published online September 13, 2018. doi:10.1001/jamaoncol.2018.3701

This large cohort study uses the SEER-Medicare database to evaluate the Medicare costs associated with diagnosis and treatment of nonmetastatic prostate cancer in men 70 years or older.

Long-term Clinical Outcomes and Biomarker Analyses of Atezolizumab Therapy for Patients With Metastatic Triple-Negative Breast CancerA Phase 1 Study

Abstract Full Text
JAMA Oncol. Published online September 13, 2018. doi:10.1001/jamaoncol.2018.4224

This phase 1 study evaluates the safety, clinical activity, and biomarkers associated with the use of single-agent atezolizumab in women with metastatic triple-negative breast cancer.

Fatal Toxic Effects Associated With Immune Checkpoint InhibitorsA Systematic Review and Meta-analysis

Abstract Full Text
has active quiz
JAMA Oncol. Published online September 13, 2018. doi:10.1001/jamaoncol.2018.3923

This systematic review and meta-analysis analyzes the incidence of regimen-specific fatal toxic effects associated with the use of immune checkpoint inhibitors for cancer treatment.

JAMA Oncology Clinical Challenge

A Lesion on the Scalp

Abstract Full Text
JAMA Oncol. Published online September 13, 2018. doi:10.1001/jamaoncol.2018.3685

A 67-year-old man presented with a rapidly enlarging, itchy scalp lesion without generalized pruritus first noticed 3 months earlier as a pimple. What is your diagnosis?

Viewpoint

Challenges in Adopting Level 1 Evidence for Multiparametric Magnetic Resonance Imaging as a Biomarker for Prostate Cancer Screening

Abstract Full Text
JAMA Oncol. Published online September 13, 2018. doi:10.1001/jamaoncol.2018.4160

This Viewpoint addresses whether there is sufficient evidence to support routine use of multiparametric magnetic resonance imaging as an adjunctive test for men with elevated prostate-specific antigen level and considers the practical implications of its widespread implementation.

September 6, 2018
Original Investigation

Disease-Free and Overall Survival Among Patients With Operable HER2-Positive Breast Cancer Treated With Sequential vs Concurrent ChemotherapyThe ACOSOG Z1041 (Alliance) Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online September 6, 2018. doi:10.1001/jamaoncol.2018.3691

This phase 3 randomized clinical trial compares disease-free and overall survival among patients with operable HER2-positive breast cancer who received concurrent vs sequential administration of neoadjuvant chemotherapy.

JAMA Oncology Patient Page

Clinical Trials, End Points, and Statistics—Measuring and Comparing Cancer Treatments in Practice

Abstract Full Text
free access
JAMA Oncol. Published online September 6, 2018. doi:10.1001/jamaoncol.2018.3708

This Patient Page defines the some of the important terms and techniques that cancer researchers use to measure and report their findings.

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