[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 18.206.12.79. Please contact the publisher to request reinstatement.
[Skip to Content Landing]

Year

Day

December 26, 2019
Original Investigation

Comparative Effectiveness of Proton vs Photon Therapy as Part of Concurrent Chemoradiotherapy for Locally Advanced Cancer

Abstract Full Text
JAMA Oncol. Published online December 26, 2019. doi:10.1001/jamaoncol.2019.4889

This comparative effectiveness study assesses whether proton therapy in the setting of concurrent chemoradiotherapy is associated with fewer 90-day unplanned hospitalizations or other adverse events and similar disease-free and overall survival compared with photon chemoradiotherapy among patients with nonmetastatic cancer.

Association Between Body Mass Index and Overall Survival With Immune Checkpoint Inhibitor Therapy for Advanced Non–Small Cell Lung Cancer

Abstract Full Text
has audio
JAMA Oncol. Published online December 26, 2019. doi:10.1001/jamaoncol.2019.5241

This cohort study examines the association between body mass index and survival in patients with non–small cell lung cancer who receive immune checkpoint inhibitor therapy.

Use of Immunotherapy With Programmed Cell Death 1 vs Programmed Cell Death Ligand 1 Inhibitors in Patients With Cancer: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA Oncol. Published online December 26, 2019. doi:10.1001/jamaoncol.2019.5367

This systematic review and meta-analysis of randomized clinical trials examines use of programmed cell death 1 (PD-1) vs programmed cell death–ligand 1 (PD-L1) treatment in patients with cancer.

Research Letter

Clinician vs Patient Reporting of Baseline and Postbaseline Symptoms for Adverse Event Assessment in Cancer Clinical Trials

Abstract Full Text
JAMA Oncol. Published online December 26, 2019. doi:10.1001/jamaoncol.2019.5566

This retrospective analysis of clinical trials compares clinician reporting of adverse events and patient reporting of analogous symptoms.

Viewpoint

Framing New Models to Expand Access to Radiotherapy in Limited Resource Settings—Social Entrepreneurship

Abstract Full Text
JAMA Oncol. Published online December 26, 2019. doi:10.1001/jamaoncol.2019.5107

This Viewpoint explores the potential for social entrepreneurship among diasporans from low- and middle-income countries to improve access to radiotherapy in their home countries.

Invited Commentary

Proton-Based Chemoradiotherapy—What Level of Evidence Is Necessary to Justify Its Widespread Use?

Abstract Full Text
JAMA Oncol. Published online December 26, 2019. doi:10.1001/jamaoncol.2019.4875
Poetry and Oncology

Delivering Good News

Abstract Full Text
JAMA Oncol. Published online December 26, 2019. doi:10.1001/jamaoncol.2019.5248
Comment & Response

BRCA Mutations and Homologous Recombination Repair Deficiency in Treatment With Niraparib Combined With Pembrolizumab

Abstract Full Text
JAMA Oncol. Published online December 26, 2019. doi:10.1001/jamaoncol.2019.4595

BRCA Mutations and Homologous Recombination Repair Deficiency in Treatment With Niraparib Combined With Pembrolizumab—Reply

Abstract Full Text
JAMA Oncol. Published online December 26, 2019. doi:10.1001/jamaoncol.2019.4601
December 19, 2019
Original Investigation

Idelalisib for Treatment of Relapsed Follicular Lymphoma and Chronic Lymphocytic Leukemia: A Comparison of Treatment Outcomes in Clinical Trial Participants vs Medicare Beneficiaries

Abstract Full Text
JAMA Oncol. Published online December 19, 2019. doi:10.1001/jamaoncol.2019.3994

This cohort study compares idelalisib treatment outcomes in the clinical setting among Medicare beneficiaries with outcomes in clinical trial data.

Clinical Evidence for Association of Acupuncture and Acupressure With Improved Cancer Pain: A Systematic Review and Meta-Analysis

Abstract Full Text
open access
JAMA Oncol. Published online December 19, 2019. doi:10.1001/jamaoncol.2019.5233

This systematic review and meta-analysis provides an updated synthesis of the published randomized clinical trials into the use and advantages of acupuncture and/or acupressure among patients with cancer pain.

The Role of Maintenance Strategies in Metastatic Colorectal Cancer: A Systematic Review and Network Meta-analysis of Randomized Clinical Trials

Abstract Full Text
has audio
JAMA Oncol. Published online December 19, 2019. doi:10.1001/jamaoncol.2019.4489

This systematic review and network meta-analysis of randomized clinical trials evaluates the comparative effectiveness of different treatment strategies in metastatic colorectal cancer.

Brief Report

Evaluation of Plasma Microbial Cell-Free DNA Sequencing to Predict Bloodstream Infection in Pediatric Patients With Relapsed or Refractory Cancer

Abstract Full Text
JAMA Oncol. Published online December 19, 2019. doi:10.1001/jamaoncol.2019.4120

This pilot cohort study estimates sensitivity and specificity of plasma microbial cell-free DNA sequencing for its ability to predict bloodstream infection in patients at high risk of life-threatening infection.

JAMA Oncology Patient Page

Ascites, or Fluid in the Belly, in Patients With Cancer

Abstract Full Text
free access
JAMA Oncol. Published online December 19, 2019. doi:10.1001/jamaoncol.2019.5409

This Patient Page describes the causes, symptoms, diagnosis, and treatment of ascites in patients with cancer.

Cancer Care Chronicles

One Patient’s Perspective on Terminal Cancer—Sometimes It Is Best Not to See

Abstract Full Text
JAMA Oncol. Published online December 19, 2019. doi:10.1001/jamaoncol.2019.5017

In this essay, the author details how his grandmother addressed a cancer diagnosis.

Comment & Response

Clinical Benefit of Circulating Tumor DNA Analysis in Early-Stage Breast Cancer

Abstract Full Text
JAMA Oncol. Published online December 19, 2019. doi:10.1001/jamaoncol.2019.5677

Clinical Benefit of Circulating Tumor DNA Analysis in Follow-up of Patients With Early-Stage Breast Cancer—Reply

Abstract Full Text
JAMA Oncol. Published online December 19, 2019. doi:10.1001/jamaoncol.2019.5682
Correction

Errors in Table

Abstract Full Text
free access
JAMA Oncol. Published online December 19, 2019. doi:10.1001/jamaoncol.2019.6210
December 12, 2019
Original Investigation

Association Between New Unconfirmed Bone Lesions and Outcomes in Men With Metastatic Castration-Resistant Prostate Cancer Treated With Enzalutamide: Secondary Analysis of the PREVAIL and AFFIRM Randomized Clinical Trials

Abstract Full Text
open access
JAMA Oncol. Published online December 12, 2019. doi:10.1001/jamaoncol.2019.4636

This secondary analysis of the PREVAIL and AFFIRM randomized clinical trials examines the association between the detection of new unconfirmed lesions detected on follow-up bone scans and outcomes in enzalutamide-treated men with metastatic castration-resistant prostate cancer (mCRPC).

Overall Survival in Men With Bone Metastases From Castration-Resistant Prostate Cancer Treated With Bone-Targeting Radioisotopes: A Meta-analysis of Individual Patient Data From Randomized Clinical Trials

Abstract Full Text
JAMA Oncol. Published online December 12, 2019. doi:10.1001/jamaoncol.2019.4097

This meta-analysis of randomized clinical trials assesses overall survival in men with bone metastases from castration-resistant prostate cancer treated with bone-targeted radioisotopes and compares the effects of α-emitting with β-emitting radioisotopes.

Comparison of Patient Age Groups in Transplantation for Myelodysplastic Syndrome: The Medicare Coverage With Evidence Development Study

Abstract Full Text
JAMA Oncol. Published online December 12, 2019. doi:10.1001/jamaoncol.2019.5140

This nonrandomized clinical trial examines the association of age with survival among Medicare beneficiaries with myelodysplastic syndrome who underwent allogeneic hematopoietic stem cell transplantation.

Research Letter

Use of Bone-Modifying Agents Among Medicare Beneficiaries With Multiple Myeloma

Abstract Full Text
JAMA Oncol. Published online December 12, 2019. doi:10.1001/jamaoncol.2019.5426

This cohort study compares the use of different bone-modifying agents among Medicare beneficiaries with multiple myeloma.

Special Communication

The Need for Combined Assessment of Multiple Outcomes in Noninferiority Trials in Oncology

Abstract Full Text
JAMA Oncol. Published online December 12, 2019. doi:10.1001/jamaoncol.2019.5361

This article makes a case for inclusion of secondary end points in noninferiority trials in oncology and provides mathematical examples of how such noninferiority might be calculated in such cases.

Review

Moving From Cancer Burden to Cancer Genomics for Smoldering Myeloma: A Review

Abstract Full Text
JAMA Oncol. Published online December 12, 2019. doi:10.1001/jamaoncol.2019.4659

This review summarizes current clinical challenges and discusses available models for risk stratification in the context of smoldering multiple myeloma.

Viewpoint

De-escalating Breast Cancer Surgery—Where Is the Tipping Point?

Abstract Full Text
JAMA Oncol. Published online December 12, 2019. doi:10.1001/jamaoncol.2019.4849

This Viewpoint provides a perspective on recent trials focused on reducing the incidence of surgery in the treatment of breast cancer.

Invited Commentary

Radioisotope Imaging and Therapy for Bone Metastasis in Men With Castration-Resistant Prostate Cancer

Abstract Full Text
JAMA Oncol. Published online December 12, 2019. doi:10.1001/jamaoncol.2019.4635

Young Enough to Undergo Allogeneic Transplantation for Myelodysplastic Syndromes?Considering the Results of the Medicare Coverage With Evidence Development Study

Abstract Full Text
JAMA Oncol. Published online December 12, 2019. doi:10.1001/jamaoncol.2019.5135
Comment & Response

Late Recurrences After Estrogen Receptor–Positive Breast Cancer

Abstract Full Text
JAMA Oncol. Published online December 12, 2019. doi:10.1001/jamaoncol.2019.5579
December 5, 2019
Original Investigation

Immune Status and Associated Mortality After Cancer Treatment Among Individuals With HIV in the Antiretroviral Therapy Era

Abstract Full Text
JAMA Oncol. Published online December 5, 2019. doi:10.1001/jamaoncol.2019.4648

This cohort study assesses the association between cancer treatment and CD4 count and RNA levels in adults with human immunodeficiency virus.

Body Composition, Adherence to Anthracycline and Taxane-Based Chemotherapy, and Survival After Nonmetastatic Breast Cancer

Abstract Full Text
JAMA Oncol. Published online December 5, 2019. doi:10.1001/jamaoncol.2019.4668

This cohort study evaluates the association between body composition and the risk of death based on the ratio of planned vs administered dose of chemotherapy in women with breast cancer.

Research Letter

Association of Sex With Toxic Effects, Treatment Adherence, and Oncologic Outcomes in the CAO/ARO/AIO-94 and CAO/ARO/AIO-04 Phase 3 Randomized Clinical Trials of Rectal Cancer

Abstract Full Text
JAMA Oncol. Published online December 5, 2019. doi:10.1001/jamaoncol.2019.5102

This pooled analysis of data from phase 3 randomized clinical trials assesses the association of sex with toxic effects, treatment adherence, surgical procedures, and long-term outcomes after standard multimodal treatment in patients with rectal cancer.

Viewpoint

Survival in Oligometastatic Prostate Cancer—A New Dawn or the Will Rogers Phenomenon?

Abstract Full Text
JAMA Oncol. Published online December 5, 2019. doi:10.1001/jamaoncol.2019.4724

This Viewpoint describes potential improvements in classification of cases of oligometastatic prostate cancer and resulting research opportunities.

Invited Commentary

Untangling the Effects of Chemotherapy and HIV on CD4 Counts—Implications for Immunotherapy in HIV and Cancer

Abstract Full Text
JAMA Oncol. Published online December 5, 2019. doi:10.1001/jamaoncol.2019.4634
Comment & Response

Exercise and Patients With Cancer—Is It Time to Get Heavier With the Dose?

Abstract Full Text
JAMA Oncol. Published online December 5, 2019. doi:10.1001/jamaoncol.2019.5404
×