This review of data from 75 families with a CDH1 pathologic variant compares estimates of the lifetime risk of gastric cancer in the families found to have a CDH1 pathologic variant through clinical ascertainment with those ascertained through multigene panel testing.
This cohort study uses data from the Southern Community Cohort Study to evaluate whether race-specific adjustment of pack-year criteria in the US Preventive Services Task Force (USPSTF) lung cancer screening guidelines is associated with more equitable screening for African American smokers at high risk for lung cancer.
This open-label, phase 2 randomized clinical trial assesses the safety of abiraterone acetate combined with 4 glucocorticoid regimens for treatment of metastatic castration-resistant prostate cancer.
This randomized clinical trial examines the effect of implementing a default order option in the electronic medical record on daily imaging utilization for patients with cancer undergoing radiotherapy during palliative care.
A woman in her 30s with a history of a renal transplant presented with right-sided, lower-extremity weakness and intermittent confusion. What is your diagnosis?
This Viewpoint presents 4 arguments against routinely substituting zoledronic acid with denosumab in patients with newly diagnosed multiple myeloma.
This population-based study links data registries on births, birth defects, and cancer diagnoses in 10 million live births in 4 US states to identify associations between birth defects and childhood cancer diagnoses and to characterize cancer risk in children with 1 or more birth defects.
This phase 2 randomized clinical trial investigates the effects of adding lapatinib to perioperative epirubicin, cisplatin, and capecitabine chemotherapy in patients with potentially curable HER2-positive gastroesophageal adenocarcinoma.
This cohort study examines the neurocognitive and neuroimaging outcomes associated with multiple use of general anesthesia in survivors of childhood acute lymphoblastic leukemia.
This survey study uses data from the National Health Interview Survey to investigate the prevalence of, and socioeconomic risk factors for, chronic pain and high-impact chronic pain among cancer survivors in the United States.
This Viewpoint describes strategies and challenges for interventional pharmacoeconomics to reduce prescribing costs while maintaining efficacy.
This open-label phase 2 clinical trial evaluates the clinical activity and safety of combination niraparib and pembrolizumab treatment in women with advanced or metastatic triple-negative breast cancer.
This open-label, single-arm, phases 1 and 2 study evaluates the poly(adenosine diphosphate–ribose) polymerase inhibitor niraparib combined with pembrolizumab in patients with recurrent ovarian carcinoma.
This randomized clinical trial assesses the effect of afatinib vs placebo after definitive chemoradiotherapy on disease-free survival in patients with head and neck squamous cell carcinoma.
This cohort study evaluates the feasibility, risks, and advantages of resuming immune checkpoint inhibitor therapy in patients with cancer who experienced severe immune-related adverse events.
This study characterizes the age disparities among trial enrollees in randomized clinical trials of common cancers (breast, prostate, colorectal, and lung cancer) in US population-based median age and identifies factors associated with age imbalances.
This open-label, nonrandomized, phase 1 study assesses the safety of pembrolizumab in patients with HIV and advanced cancer.
This study assesses tumor-stroma proportion and compares this finding with the development of resistance to platinum-based chemotherapy in women newly diagnosed with ovarian carcinoma.
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