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Year

Day

April 30, 2020
Original Investigation

Efficacy of Nivolumab and AVD in Early-Stage Unfavorable Classic Hodgkin Lymphoma: The Randomized Phase 2 German Hodgkin Study Group NIVAHL Trial

Abstract Full Text
JAMA Oncol. Published online April 30, 2020. doi:10.1001/jamaoncol.2020.0750

This phase 2 randomized clinical trial assesses the efficacy of concomitant and sequential treatment with nivolumab and doxorubicin, vinblastine, and dacarbazine (AVD) for patients with early-stage unfavorable Hodgkin lymphoma.

A Phase 2 Multi-institutional Study of Nivolumab for Patients With Advanced Refractory Biliary Tract Cancer

Abstract Full Text
JAMA Oncol. Published online April 30, 2020. doi:10.1001/jamaoncol.2020.0930

This multicenter phase 2 study evaluates the anticancer activity of nivolumab in patients with advanced refractory biliary tract cancer.

Research Letter

Association of Behavioral Nudges With High-Value Evidence-Based Prescribing in Oncology

Abstract Full Text
JAMA Oncol. Published online April 30, 2020. doi:10.1001/jamaoncol.2020.0746

This interrupted time series analysis evaluates the association of nudges with zoledronate prescription vs more expensive denosumab.

Trends in Provision of Palliative Radiotherapy and Chemotherapy Among Hospices in the United States, 2011-2018

Abstract Full Text
JAMA Oncol. Published online April 30, 2020. doi:10.1001/jamaoncol.2020.0923

This case series study uses Medicare 2011-2019 Hospice Cost Report Data to analyze trends in the proportion of freestanding hospices in the United States providing radiotherapy and chemotherapy, as well as the expenses incurred for providing these therapies.

Cancer Care Chronicles

The Importance of Physician Attire—The Socks With the Bulls

Abstract Full Text
JAMA Oncol. Published online April 30, 2020. doi:10.1001/jamaoncol.2020.0577

This article discusses the role of a physician’s attire in patient perception of their physician.

Comment & Response

Immunotherapy With Programmed Cell Death 1 vs Programmed Cell Death Ligand 1 Inhibitors in Patients With Cancer

Abstract Full Text
JAMA Oncol. Published online April 30, 2020. doi:10.1001/jamaoncol.2020.0625

Immunotherapy With Programmed Cell Death 1 vs Programmed Cell Death Ligand 1 Inhibitors in Patients With Cancer

Abstract Full Text
JAMA Oncol. Published online April 30, 2020. doi:10.1001/jamaoncol.2020.0628

Immunotherapy With Programmed Cell Death 1 vs Programmed Cell Death Ligand 1 Inhibitors in Patients With Cancer

Abstract Full Text
JAMA Oncol. Published online April 30, 2020. doi:10.1001/jamaoncol.2020.0631

Immunotherapy With Programmed Cell Death 1 vs Programmed Cell Death Ligand 1 Inhibitors in Patients With Cancer

Abstract Full Text
JAMA Oncol. Published online April 30, 2020. doi:10.1001/jamaoncol.2020.0637

Immunotherapy With Programmed Cell Death 1 vs Programmed Cell Death Ligand 1 Inhibitors in Patients With Cancer—Reply

Abstract Full Text
JAMA Oncol. Published online April 30, 2020. doi:10.1001/jamaoncol.2020.0646
April 24, 2020
Cancer Care Chronicles

Facing a Pandemic While Pregnant

Abstract Full Text
free access has active quiz
JAMA Oncol. Published online April 24, 2020. doi:10.1001/jamaoncol.2020.1652

In this essay, the author describes her experience being pregnant during the coronavirus disease 2019 pandemic.

April 23, 2020
Original Investigation

Factors Associated With Chemoradiation Therapy Interruption and Noncompletion Among Patients With Squamous Cell Anal Carcinoma

Abstract Full Text
JAMA Oncol. Published online April 23, 2020. doi:10.1001/jamaoncol.2020.0809

This cohort study examines rates of chemoradiation treatment interruption or noncompletion and identifies factors associated with this among patients with anal cancer treated in routine clinical practice.

Research Letter

Central Nervous System as Possible Site of Relapse in ERBB2-Positive Metastatic Colorectal Cancer: Long-term Results of Treatment With Trastuzumab and Lapatinib

Abstract Full Text
JAMA Oncol. Published online April 23, 2020. doi:10.1001/jamaoncol.2020.0571

This secondary analysis of data from the HERACLES-A clinical trial examines long-term outcomes in 32 patients with colorectal cancer treated with trastuzumab and lapatinib.

Staying at One’s Job to Maintain Employer-Based Health Insurance Among Cancer Survivors and Their Spouses/Partners

Abstract Full Text
JAMA Oncol. Published online April 23, 2020. doi:10.1001/jamaoncol.2020.0742

This study examines the prevalence at which cancer survivors and their spouses/partners in the US stay at their jobs to maintain employer-based health insurance.

JAMA Oncology Clinical Challenge

Cardiac Masses in a Patient With Pancreatic Adenocarcinoma and a History of Breast Carcinoma

Abstract Full Text
has active quiz
JAMA Oncol. Published online April 23, 2020. doi:10.1001/jamaoncol.2020.0086

A 64-year-old woman with borderline resectable pancreatic adenocarcinoma and a history of hormone receptor–positive left-sided breast cancer had several hypodense lesions in the apex of her heart on chest computed tomography and several discrete, partially mobile frondlike masses originating from her cardiac apex on transthoracic echocardiography. What is your diagnosis?

Comment & Response

Association of Acupuncture and Acupressure With Improved Cancer Pain

Abstract Full Text
JAMA Oncol. Published online April 23, 2020. doi:10.1001/jamaoncol.2020.0616

Association of Acupuncture and Acupressure With Improved Cancer Pain

Abstract Full Text
JAMA Oncol. Published online April 23, 2020. doi:10.1001/jamaoncol.2020.0619

Association of Acupuncture and Acupressure With Improved Cancer Pain

Abstract Full Text
JAMA Oncol. Published online April 23, 2020. doi:10.1001/jamaoncol.2020.0622

Association of Acupuncture and Acupressure With Improved Cancer Pain—Reply

Abstract Full Text
JAMA Oncol. Published online April 23, 2020. doi:10.1001/jamaoncol.2020.0640

Obesity Paradox in Patients With Non–Small Cell Lung Cancer Treated With Immunotherapy

Abstract Full Text
JAMA Oncol. Published online April 23, 2020. doi:10.1001/jamaoncol.2020.0634

Obesity Paradox in Patients With Non–Small Cell Lung Cancer Treated With Immunotherapy—Reply

Abstract Full Text
JAMA Oncol. Published online April 23, 2020. doi:10.1001/jamaoncol.2020.0643
April 16, 2020
Original Investigation

Immune Checkpoint Inhibitor Rechallenge After Immune-Related Adverse Events in Patients With Cancer

Abstract Full Text
has audio
JAMA Oncol. Published online April 16, 2020. doi:10.1001/jamaoncol.2020.0726

This cohort study examines case reports from a large, international pharmacovigilance database to determine the recurrence rate of adverse events associated with continuing immunotherapy drugs for patients with cancer.

Association of Utilization Management Policy With Uptake of Hypofractionated Radiotherapy Among Patients With Early-Stage Breast Cancer

Abstract Full Text
JAMA Oncol. Published online April 16, 2020. doi:10.1001/jamaoncol.2020.0449

This economic analysis assesses the association of a large commercial payer’s utilization management policy with use of hypofractionated radiotherapy and associated spending among women with early-stage breast cancer.

Research Letter

Positron Emission Tomography Imaging of Poly–(Adenosine Diphosphate–Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online April 16, 2020. doi:10.1001/jamaoncol.2020.0334

This nonrandomized clinical trial tested [18F]FluorThanatrace as a method for measuring regional poly–(adenosine diphosphate–ribose) polymerase 1 expression in breast cancer and as a potential functional biomarker for breast cancer poly–(adenosine diphosphate–ribose) polymerase inhibitor response.

The Use of Not-Negative Conclusions to Describe Results of Formally Negative Trials Presented at Oncology Meetings

Abstract Full Text
JAMA Oncol. Published online April 16, 2020. doi:10.1001/jamaoncol.2020.0475

This quality improvement analysis of oral presentations of phase 3 randomized clinical trials evaluates the frequency and risks of emphasizing results of borderline significance.

Review

Assessment of Therapy-Related Myeloid Neoplasms in Patients With Neuroendocrine Tumors After Peptide Receptor Radionuclide Therapy: A Systematic Review

Abstract Full Text
JAMA Oncol. Published online April 16, 2020. doi:10.1001/jamaoncol.2020.0078

This systematic review evaluates the literature and report the incidence, time of diagnosis, and nature of therapy-related myeloid neoplasms after peptide receptor radionuclide therapy.

Invited Commentary

Evaluating a Utilization Management Policy in Radiation Oncology

Abstract Full Text
JAMA Oncol. Published online April 16, 2020. doi:10.1001/jamaoncol.2020.0447
Poetry and Oncology

Bone Marrow Biopsy

Abstract Full Text
JAMA Oncol. Published online April 16, 2020. doi:10.1001/jamaoncol.2020.0388
Comment & Response

Defining the Right State for a Will Rogers Phenomenon in Oligometastatic Prostate Cancer

Abstract Full Text
JAMA Oncol. Published online April 16, 2020. doi:10.1001/jamaoncol.2020.0574

The Role of Maintenance Therapy in Metastatic Colorectal Cancer

Abstract Full Text
JAMA Oncol. Published online April 16, 2020. doi:10.1001/jamaoncol.2020.0580

The Role of Maintenance Therapy in Metastatic Colorectal Cancer—Reply

Abstract Full Text
JAMA Oncol. Published online April 16, 2020. doi:10.1001/jamaoncol.2020.0583
April 10, 2020
Cancer Care Chronicles

Caring for Patients With Cancer During the COVID-19 Outbreak in Italy

Abstract Full Text
free access has active quiz
JAMA Oncol. Published online April 10, 2020. doi:10.1001/jamaoncol.2020.1426

This essay discusses the challenges associated with caring for patients with cancer during the COVID-19 epidemic in Italy.

April 9, 2020
Original Investigation

Efficacy and Safety of Pembrolizumab Plus Docetaxel vs Docetaxel Alone in Patients With Previously Treated Advanced Non–Small Cell Lung Cancer: The PROLUNG Phase 2 Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online April 9, 2020. doi:10.1001/jamaoncol.2020.0409

This phase 2 randomized clinical trial evaluates the safety and efficacy of the combination treatment of pembrolizumab plus docetaxel vs docetaxel alone in patients with previously treated advanced non–small cell lung cancer.

Brief Report

Assessment of the Feasibility and Safety of Durvalumab for Treatment of Solid Tumors in Patients With HIV-1 Infection: The Phase 2 DURVAST Study

Abstract Full Text
JAMA Oncol. Published online April 9, 2020. doi:10.1001/jamaoncol.2020.0465

This nonrandomized phase 2 study assesses the feasibility and safety of durvalumab treatment in adults with advanced solid tumors and HIV-1 infection.

Research Letter

e-Cigarette Use Among Young Adult Cancer Survivors Relative to the US Population

Abstract Full Text
JAMA Oncol. Published online April 9, 2020. doi:10.1001/jamaoncol.2020.0384

This survey study uses data from the 2018 Behavioral Risk Factor Surveillance System survey to evaluate e-cigarette use in young adults who have a history of cancer relative to young adults without cancer.

Viewpoint

Supervision Requirements in the 2020 Hospital Outpatient Prospective Payment System: Implications for Cancer Care in the United States

Abstract Full Text
JAMA Oncol. Published online April 9, 2020. doi:10.1001/jamaoncol.2020.0092

This Viewpoint discusses the Centers for Medicare and Medicaid Services new rule for the Hospital Outpatient Prospective Payment System and the possible implications for patient safety and quality of care for patients with cancer.

Comment & Response

Locoregional Therapy Plus Systemic Chemotherapy in Unresectable Intrahepatic Cholangiocarcinoma

Abstract Full Text
JAMA Oncol. Published online April 9, 2020. doi:10.1001/jamaoncol.2020.0340

Locoregional Therapy Plus Systemic Chemotherapy in Unresectable Intrahepatic Cholangiocarcinoma—Reply

Abstract Full Text
JAMA Oncol. Published online April 9, 2020. doi:10.1001/jamaoncol.2020.0343
April 2, 2020
Original Investigation

Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival: Long-term Results From the TARGIT-A Randomized Clinical Trial in Early Breast Cancer

Abstract Full Text
open access
JAMA Oncol. Published online April 2, 2020. doi:10.1001/jamaoncol.2020.0249

This secondary analysis of the TARGIT-A randomized clinical trial compares the effect of delayed second-procedure targeted intraoperative radiotherapy (TARGIT-IORT) with whole-breast external beam radiotherapy (ERBT) on local recurrence at 5 years and long-term survival outcomes among women with early breast cancer.

Association Between Breastfeeding and Ovarian Cancer Risk

Abstract Full Text
JAMA Oncol. Published online April 2, 2020. doi:10.1001/jamaoncol.2020.0421

This pooled analysis analyzes the association between breastfeeding (ie, ever/never, duration, timing) and ovarian cancer risk overall and by histotype.

Viewpoint

Better Understanding the Importance of Palliative Care for Pediatric Patients

Abstract Full Text
JAMA Oncol. Published online April 2, 2020. doi:10.1001/jamaoncol.2020.0083

This Viewpoint discusses issues involved in implementing palliative care programs for pediatric patients.

Comment & Response

Circulating Tumor DNA as a Prognostic Marker in Stage III Colon Cancer

Abstract Full Text
JAMA Oncol. Published online April 2, 2020. doi:10.1001/jamaoncol.2020.0283

Circulating Tumor DNA as a Prognostic Marker in Stage III Colon Cancer—Reply

Abstract Full Text
JAMA Oncol. Published online April 2, 2020. doi:10.1001/jamaoncol.2020.0289
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