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September 16, 2021
Original Investigation

Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clinical Trial

Abstract Full Text
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JAMA Oncol. Published online September 16, 2021. doi:10.1001/jamaoncol.2021.3690

This randomized clinical trial examines the distribution and prognosis of residual cancer burden across high-risk phenotypic subtypes of breast cancer and by different treatment groups.

Risk of Pancreatic Cancer Among Individuals With Pathogenic Variants in the ATM Gene

Abstract Full Text
JAMA Oncol. Published online September 16, 2021. doi:10.1001/jamaoncol.2021.3701

This was a multicenter cohort study of pancreatic cancer family registries in the US and Canada examines age-specific penetrance of pancreatic cancer in individuals with pathogenic variants in the ATM gene.

Diagnostic Accuracy of 68Ga-PSMA-11 PET for Pelvic Nodal Metastasis Detection Prior to Radical Prostatectomy and Pelvic Lymph Node Dissection: A Multicenter Prospective Phase 3 Imaging Trial

Abstract Full Text
JAMA Oncol. Published online September 16, 2021. doi:10.1001/jamaoncol.2021.3771

This single-arm diagnostic imaging trial assesses the accuracy of 68Ga-PSMA-11 positron emission tomographic imaging in detecting pelvic nodal metastases compared with histopathology.

Carfilzomib, Lenalidomide, and Dexamethasone Followed by Lenalidomide Maintenance for Prevention of Symptomatic Multiple Myeloma in Patients With High-risk Smoldering Myeloma: A Phase 2 Nonrandomized Controlled Trial

Abstract Full Text
JAMA Oncol. Published online September 16, 2021. doi:10.1001/jamaoncol.2021.3971

This phase 2 nonrandomized controlled trial investigates the use of carfilzomib, lenalidomide, and dexamethasone followed by lenalidomide maintenance therapy for the prevention of symptomatic multiple myeloma in patients with high-risk smoldering myeloma.

Invited Commentary

Prostate-Specific Membrane Antigen Positron Emission Tomography and the New Algorithm for Patients With Prostate Cancer Prior to Prostatectomy

Abstract Full Text
JAMA Oncol. Published online September 16, 2021. doi:10.1001/jamaoncol.2021.3762
Comment & Response

Is Colorectal Cancer Screening Absolutely Beneficial for Older Adults?

Abstract Full Text
JAMA Oncol. Published online September 16, 2021. doi:10.1001/jamaoncol.2021.4152

Is Colorectal Cancer Screening Absolutely Beneficial for Older Adults?

Abstract Full Text
JAMA Oncol. Published online September 16, 2021. doi:10.1001/jamaoncol.2021.4155
September 14, 2021
Editorial

Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma—Renewed Enthusiasm and a Lingering Challenge

Abstract Full Text
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JAMA Oncol. Published online September 14, 2021. doi:10.1001/jamaoncol.2021.4410
September 9, 2021
Original Investigation

Trends in Late Mortality and Life Expectancy After Allogeneic Blood or Marrow Transplantation Over 4 Decades: A Blood or Marrow Transplant Survivor Study Report

Abstract Full Text
JAMA Oncol. Published online September 9, 2021. doi:10.1001/jamaoncol.2021.3676

This cohort study examines changes in late mortality and life expectancy in individuals who received blood or bone marrow transplantation from 1974 to 2014.

Review

Neoadjuvant Endocrine Therapy in Clinical Practice: A Review

Abstract Full Text
JAMA Oncol. Published online September 9, 2021. doi:10.1001/jamaoncol.2021.2132

This review summarizes clinical aspects related to the application of neoadjuvant endocrine therapy in the treatment of hormone receptor–positive/ERBB2-negative breast cancer.

Viewpoint

Inferential Challenges for Real-world Evidence in the Era of Routinely Collected Health Data: Many Researchers, Many More Hypotheses, a Single Database

Abstract Full Text
JAMA Oncol. Published online September 9, 2021. doi:10.1001/jamaoncol.2021.3537

This Viewpoint discusses how biases associated with selective inference and multiple testing can potentially invalidate the conclusions of studies using routinely collected health data.

Editorial

Life Expectancy After Allogeneic Stem Cell Transplant—In It for the Long Haul?

Abstract Full Text
JAMA Oncol. Published online September 9, 2021. doi:10.1001/jamaoncol.2021.3674
Comment & Response

What Is the Optimal Treatment for Vulnerable Older Women With Ovarian Cancer?

Abstract Full Text
JAMA Oncol. Published online September 9, 2021. doi:10.1001/jamaoncol.2021.4125

What Is the Optimal Treatment for Vulnerable Older Women With Ovarian Cancer?

Abstract Full Text
JAMA Oncol. Published online September 9, 2021. doi:10.1001/jamaoncol.2021.4128

What Is the Optimal Treatment for Vulnerable Older Women With Ovarian Cancer?—Reply

Abstract Full Text
JAMA Oncol. Published online September 9, 2021. doi:10.1001/jamaoncol.2021.4131
September 2, 2021
Original Investigation

Ensartinib vs Crizotinib for Patients With Anaplastic Lymphoma Kinase−Positive Non–Small Cell Lung Cancer: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Oncol. Published online September 2, 2021. doi:10.1001/jamaoncol.2021.3523

This randomized clinical trial compares ensartinib with crizotinib among patients with advanced anaplastic lymphoma kinase (ALK)–positive non–small cell lung cancer (NSCLC) who had not received prior treatment with an ALK inhibitor.

Projected Association of Human Papillomavirus Vaccination With Oropharynx Cancer Incidence in the US, 2020-2045

Abstract Full Text
JAMA Oncol. Published online September 2, 2021. doi:10.1001/jamaoncol.2021.2907

This age-period-cohort analysis examines whether human papillomavirus vaccination will alter the incidence of oropharynx cancer through 2045.

Review

COVID-19 and Cancer: A Review of the Registry-Based Pandemic Response

Abstract Full Text
free access
JAMA Oncol. Published online September 2, 2021. doi:10.1001/jamaoncol.2021.4083

This review describes the registry efforts made during the COVID-19 pandemic with the aim of investigating and sharing information about the history, risk factors, and outcomes of patients with COVID-19 and cancer.

JAMA Oncology Clinical Challenge

Unilateral Leg Swelling in a Young Woman

Abstract Full Text
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JAMA Oncol. Published online September 2, 2021. doi:10.1001/jamaoncol.2021.3811

A 33-year-old woman with a history of hereditary bilateral retinoblastoma as an infant presents with 1 week of right lower extremity swelling. What is your diagnosis?

Viewpoint

Information Blocking and Oncology: Implications of the 21st Century Cures Act and Open Notes

Abstract Full Text
JAMA Oncol. Published online September 2, 2021. doi:10.1001/jamaoncol.2021.3520

This Viewpoint describes perceived benefits and risks of open notes in cancer treatment and their effects on the patient-physician relationship.

Editorial

Inserting Ensartinib Into the Starting Lineup for ALK-Rearranged Lung Cancer—A Likely Limited Role on a Deep Bench

Abstract Full Text
JAMA Oncol. Published online September 2, 2021. doi:10.1001/jamaoncol.2021.3369
Comment & Response

Quantifying and Interpreting Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Cancer Control for Advanced Gastroesophageal Cancer Among an Older Population

Abstract Full Text
JAMA Oncol. Published online September 2, 2021. doi:10.1001/jamaoncol.2021.4004

Quantifying and Interpreting Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Cancer Control for Advanced Gastroesophageal Cancer Among an Older Population

Abstract Full Text
JAMA Oncol. Published online September 2, 2021. doi:10.1001/jamaoncol.2021.4007

Quantifying and Interpreting Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Cancer Control for Advanced Gastroesophageal Cancer Among an Older Population—Reply

Abstract Full Text
JAMA Oncol. Published online September 2, 2021. doi:10.1001/jamaoncol.2021.4010
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