This annual, always anticipated edition of the Archives is titled “Worldwide,” not “International.” Seemingly subtle differences in nomenclature sometimes denote marked differences in perspective. Too frequently, “international” has come to connote “second class,” something that would not, ordinarily, make the grade. Not so here. “Worldwide” makes it clear that important insights and contributions can arise anywhere in the world. As medical perspectives and concerns differ between countries, particularly those that are rich and those that are poor, so will the contributions of their ophthalmologists and ophthalmic scientists. As this special issue makes clear, ophthalmology has increasingly gone global.