Dr Naumann touches on an important area of corneal endothelial involvement in PXS. He showed nicely that there does appear to be a real PXS keratopathy that may result in diffuse corneal endothelial decompensation by examining 7 corneal specimens in patients with PXS.1 Ehlers et al2 related the central corneal thickness to other biometric parameters among 3 groups of patients: those with open-angle glaucoma, those with ocular hypertension, and those with PXS. Cornea thickness was normal in open-angle glaucoma but significantly (P<.001) increased in ocular hypertension. The central corneal thickness among the group with PXS was slightly, but not significantly (P<.01) higher than normal.
Herndon LW. Corneal Thickness and Applanation Pressure—Reply. Arch Ophthalmol. 1998;116(5):701. doi:
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