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March 2001

Additional Considerations in Cases Involving Persistent Hyperplastic Primary Vitreous

Arch Ophthalmol. 2001;119(3):457-458. doi:

I read with interest the case reported by Lauer et al.1 In such cases it is important to obtain a careful, detailed, and accurate history of any drug abuse by the mother during pregnancy, because persistent hyperplastic primary vitreous (PHPV) may be associated with maternal cocaine2 and lysergic acid diethylamide3 use. In addition, it is extremely important to examine these cases thoroughly, because many ocular and systemic abnormalities are associated with PHPV. Ocular associations include microphthalmos, megalocornea, Peters anomaly, cataract colobomas, retinal detachment with retinal dysplasia,4 intraocular cartilage,3 and homonymous hemianopia.5 Important systemic associations include hemiparesis, impaired coordination, ataxia, hypotonia, spastic quadriplegia, microcephaly, and deafness,5 as well as arachnoid cysts, syndactyly, congenital heart anomalies, pulmonary atresia, asplenia,6 and Aicardi syndrome.7

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