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January 2002

Epithelial Origin of "Stromal" Corneal Dystrophies

Arch Ophthalmol. 2002;120(1):101. doi:

In reply

We agree that Drs Witschel and Sundmacher provided important evidence of the epithelial genesis of granular corneal dystrophy in their 1979 article, and we appreciate their letter calling our attention to this fact. Their article also provided a useful review of older literature on the histopathology of granular dystrophy, which had led some authors to the reasonable but incorrect conclusion that the stromal deposits were produced by the keratinocytes rather than by the epithelial cells.

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