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December 2002

Screening for Pineoblastoma in Patients With Retinoblastoma

Arch Ophthalmol. 2002;120(12):1774. doi:

In reply

We appreciated the interest that Moll et al have shown in our work. They bring an important conclusion from our study to the attention of the reader, that considering the use of routine neuroimaging to detect intracranial tumors in patients with retinoblastoma is warranted. Moll et al suggest using routine neuroimaging only in patients with familial retinoblastoma because these patients are at highest risk for development of PNET. However, in our series, 1 of 86 patients with recognized heritable retinoblastoma who was screened routinely at 5-month intervals developed PNET between routine screenings, and 2 of the 3 patients in the series who developed PNET were not recognized as having heritable retinoblastoma and did not undergo routine neuroimaging. By routinely imaging only patients with recognized familial retinoblastoma, only one third of patients in our admittedly small series who developed PNET would be imaged.

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