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July 2001

Increasing the Efficiency of Photodynamic Therapy in the Treatment of Subretinal Neovascularization

Arch Ophthalmol. 2001;119(7):1086. doi:

In reply

We thank Dr Jonas for his suggestion to modify the technique of photodynamic therapy for the treatment of choroidal neovascularization (CNV).

It is important for investigators and ophthalmologists to learn new treatment strategies. Photodynamic therapy is a novel modality that differs substantially from previous approaches. Unlike laser photocoagulation, the laser energy administered in this technique plays a minor role. The energy levels used do not have any thermal effect, and heat transport due to active perfusion is irrelevant. The effect of light activation is purely chemical and is used to induce oxidative mechanisms.1 Currently, 600 mW/cm2 of light are used, approximately 6 times the dose required to induce photo-oxidation.