It is an important consideration for all health care practitioners to be aware of generic medication problems in this environment of generic and therapeutic drug substitution. While regulations governing the manufacture of generic products require that all products meet certain uniform standards, careful postmarketing surveillance is essential in assuring such standards. We recently encountered problems with a generic 1% prednisolone acetate ophthalmic suspension when our buying group switched from a brand name to a generic product considered more cost-effective. Previously, the name brand Pred Forte (1% prednisolone acetate suspension, Allergan, Irvine, Calif) had always been purchased and dispensed at our institutions. Pred Forte, a suspension, requires shaking by the patient prior to use and generally goes into suspension easily with minimal shaking.
Fiscella RG, Jensen M, Van Dyck G. Generic Prednisolone Suspension Substitution. Arch Ophthalmol. 1998;116(5):703. doi:https://doi.org/
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