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Oct 2012

Effect of Cataract Surgery and 5-Fluorouracil on Trabeculectomy Function

Author Affiliations

Author Affiliations: Division of Glaucoma, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida.

Arch Ophthalmol. 2012;130(10):1353-1354. doi:10.1001/archophthalmol.2012.1506

We discussed the article titled “Cataract Surgery After Trabeculectomy: The Effect on Trabeculectomy Function”1 by Husain and coworkers that was published in the February 2012 issue of the Archives at a meeting of the Glaucoma Journal Club of Bascom Palmer Eye Institute on February 24, 2012. The article asserts in the abstract and results that “the time from trabeculectomy to cataract surgery was significantly associated with time to trabeculectomy failure”1 and provides hazard ratios for eyes that underwent cataract surgery within 6 months, 1 year, and 2 years after trabeculectomy. We noted in Table 2 that the number and percentage of trabeculectomy failures was higher in the noncataract surgery group than in the cataract surgery group, 57 (41.3%) vs 22 (22.7%), respectively. From these data, it appears that cataract surgery is actually a protective factor against bleb failure, which seems counterintuitive.