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Oct 2012

Effect of Cataract Surgery and 5-Fluorouracil on Trabeculectomy Function—Reply

Author Affiliations

Author Affiliations: Singapore National Eye Centre and Singapore Eye Research Institute (Drs Husain and Aung) and Yong Loo Lin School of Medicine, National University of Singapore (Dr Aung), Singapore.

Arch Ophthalmol. 2012;130(10):1353-1354. doi:10.1001/archophthalmol.2012.2290

In reply

We thank Chen and colleagues for their comments on our article.1 They raised 2 questions. First, they pointed out that the group who did not have cataract surgery had more trabeculectomy failures than the group who had undergone cataract surgery, which seems contradictory to our conclusion that having cataract surgery was significantly associated with trabeculectomy failure. The second question concerned seemingly different results from our analysis compared with the results from the associated article by Wong et al2 from the Singapore 5-fluorouracil trabeculectomy study. Chen and colleagues assert that intraoperative use of 5-fluorouracil was not associated with less failure in our analysis, but it was in the former.