The diagnosis of autoimmune retinopathy (AIR) is primarily based on clinical examination and abnormal electroretinographic and visual field testing findings. Antiretinal antibody (ARA) detection is used to support the diagnosis, but its interpretation is limited by our incomplete understanding of which ARAs are pathogenic and the lack of uniform laboratory methods. Western blot is one ARA detection method that is not standardized.1-4 To determine whether different laboratory techniques affect results in a real-life setting, we compared ARA results from 2 laboratories in patients with AIR.