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January 2013

Concordance of Antiretinal Antibody Testing Results Between Laboratories in Autoimmune Retinopathy

Author Affiliations

Author Affiliations: Uveitis (Drs Faez and Sobrin) and Retina (Drs Loewenstein and Sobrin) Services, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston.

JAMA Ophthalmol. 2013;131(1):113-115. doi:10.1001/jamaophthalmol.2013.574

The diagnosis of autoimmune retinopathy (AIR) is primarily based on clinical examination and abnormal electroretinographic and visual field testing findings. Antiretinal antibody (ARA) detection is used to support the diagnosis, but its interpretation is limited by our incomplete understanding of which ARAs are pathogenic and the lack of uniform laboratory methods. Western blot is one ARA detection method that is not standardized.1-4 To determine whether different laboratory techniques affect results in a real-life setting, we compared ARA results from 2 laboratories in patients with AIR.