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January 2013

Optic Disc Edema From Remote Uveal Melanoma

Author Affiliations

Author Affiliations: Havener Eye Institute, Department of Ophthalmology and Vision Science (Drs Clark, Lubow, Davidorf, Abdel-Rahman, and Cebulla), Department of Pathology (Dr Ray-Chaudhury), and Division of Human Genetics (Dr Abdel-Rahman), The Ohio State University, Columbus.

JAMA Ophthalmol. 2013;131(1):115-117. doi:10.1001/jamaophthalmol.2013.575

Uveal melanoma is associated with local ocular effects including retinal detachment and macular edema,1 but few reports detail the remote effects on the optic nerve. Two cases of optic nerve head leakage on angiography are reported in patients with uveal melanoma.2 These cases had melanoma cells adjacent to or in the optic nerve, and the changes were attributed to direct effects of the tumor. We describe a patient with uveal melanoma, remote from the optic nerve, who showed optic disc fluorescein leakage despite no direct tumor association on histopathologic analysis.