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June 2013

Histopathologic, Immunohistochemical, and Cytogenetic Analysis of Primary Clear Cell Melanoma of the Uvea

Author Affiliations

Author Affiliations: Departments of Pathology (Dr Verdijk), Ophthalmology (Drs Koopmans and Kilic), and Clinical Genetics (Drs Koopmans and de Klein), Erasmus MC University, and Rotterdam Eye Hospital (Dr Paridaens), Rotterdam, the Netherlands.

JAMA Ophthalmol. 2013;131(6):814-816. doi:10.1001/jamaophthalmol.2013.1939

The histologic findings of malignant melanoma may be highly variable, and the tumor can mimic many other neoplasms.1 We describe a case of clear cell uveal melanoma. Cytoplasmic clear cell change of uveal melanoma cells can be observed as balloon cells,1 clear cells,2 and signet ring cells.1 The histologic differential diagnosis has to be made with metastatic clear cell carcinomas, seminoma, and clear cell sarcoma as well as xanthomatous cells.

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