Intraocular tumors are a recognized cause of secondary glaucoma. Mechanisms of tumor-related glaucoma include direct tumor invasion or infiltration of the anterior chamber angle, pupillary block caused by anterior displacement of iris-lens diaphragm in the eyes with tumors located posterior to the iris, melanomalytic or melanocytomalytic glaucoma, tumor-induced neovascular glaucoma, inflammatory glaucoma secondary to tumor necrosis, hemolytic glaucoma, and glaucoma due to elevated episcleral venous pressure secondary to extraocular tumor extension.1 A survey of 2704 eyes with intraocular tumors revealed tumor-related glaucoma in 126 eyes (5%) including uveal melanoma (55 of 2111 [3%]), uveal metastases (12 of 256 [5%]), retinoblastoma (51 of 303 [17%]), intraocular lymphoma (3 of 11 [27%]), intraocular leukemia (1 of 11 [9%]), ciliary body medulloepithelioma (2 of 2 [100%]), iris melanocytoma (1 of 1 [100%]), and iris pigment epithelial adenoma (1 of 2 [50%]).1
Kaliki S, Eagle RC, Grossniklaus HE, Campbell RJ, Shields CL, Shields JA. Inadvertent Implantation of Aqueous Tube Shunts in Glaucomatous Eyes With Unrecognized Intraocular Neoplasms: Report of 5 Cases. JAMA Ophthalmol. 2013;131(7):925–928. doi:10.1001/jamaophthalmol.2013.828
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