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The article by Bhavsar et al is most important,1 as there is a lack of prospective studies assessing the necessity of antibiotics after intravitreal injection. However, if the endophthalmitis were to occur in the disgruntled mother of a persuasive lawyer, we do not know whether such data would be more valid than a retrospective series of similar sample size but with more consistent treatment protocols (and thus fewer confounding factors).
Ziemssen F, Bartz-Schmidt KU. Topical Antibiotics to Reduce the Risk of Endophthalmitis After Intravitreal Injection?. Arch Ophthalmol. 2010;128(9):1224–1225. doi:10.1001/archophthalmol.2010.173
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