Central retinal vein occlusion (CRVO) severely threatens vision, especially in ischemic CRVO, for which no effective treatment has been established. Photocoagulation is the only treatment for retinal ischemia, which restores a balance between oxygen supply and demand by reducing the number of retinal cells. Considering its destructiveness, photocoagulation is not ideal. We report 2 cases with ischemic CRVO in which reperfusion of large ischemic areas occurred after novel treatment with an intraocular injection of activated protein C (APC).
Kamei M, Matsumura N, Suzuki M, Sakimoto S, Sakaguchi H, Nishida K. Reperfusion of Large Ischemic Areas Associated With Central Retinal Vein Occlusion: A Potential Novel Treatment With Activated Protein C. JAMA Ophthalmol. 2014;132(3):361–362. doi:10.1001/jamaophthalmol.2013.6334
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