Descemet stripping automated endothelial keratoplasty (DSAEK) has become the preferred surgical treatment for patients with endothelial dysfunction.1 Interface fluid syndrome (IFS) is an uncommon complication after laser-assisted in situ keratomileusis (LASIK) in which diffuse pockets of fluid collect within the interface. Typical cases of IFS are associated with steroid-induced intraoperative pressure (IOP) increase after LASIK.2,3 We describe a patient who had undergone anterior chamber phakic intraocular lens (IOL) implantation and LASIK for high myopia. Five years later, she required DSAEK owing to endothelial dysfunction. She presented with IFS in the immediate postoperative period.