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A unique case of diffuse retinal ischemia following intravenous abuse of crushed extended-release oxymorphone hydrochloride (Opana ER) is reported. This case highlights a potentially blinding condition as a result of retinal vascular endothelial injury following intravenous abuse of a medication intended for oral use.
A 46-year-old man presented with a 2-month history of bilateral, painless, progressive vision loss. He acknowledged using crushed oxymorphone intravenously on 8 separate occasions during a 1-month period prior to the vision loss. He had no ocular history. His medical history included hepatitis B and controlled hypertension. His medications included lisinopril and oxycodone hydrochloride. He denied any allergies and smoked cigarettes (1 pack/d). Despite occasional fevers and chills, his review of systems was negative. He denied any recent trauma or systemic illness.
Shah RJ, Cherney EF. Diffuse Retinal Ischemia Following Intravenous Crushed Oxymorphone Abuse. JAMA Ophthalmol. 2014;132(6):780–781. doi:10.1001/jamaophthalmol.2014.324
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