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June 2014

Diffuse Retinal Ischemia Following Intravenous Crushed Oxymorphone Abuse

Author Affiliations
  • 1Vanderbilt Eye Institute, Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee
JAMA Ophthalmol. 2014;132(6):780-781. doi:10.1001/jamaophthalmol.2014.324

A unique case of diffuse retinal ischemia following intravenous abuse of crushed extended-release oxymorphone hydrochloride (Opana ER) is reported. This case highlights a potentially blinding condition as a result of retinal vascular endothelial injury following intravenous abuse of a medication intended for oral use.

A 46-year-old man presented with a 2-month history of bilateral, painless, progressive vision loss. He acknowledged using crushed oxymorphone intravenously on 8 separate occasions during a 1-month period prior to the vision loss. He had no ocular history. His medical history included hepatitis B and controlled hypertension. His medications included lisinopril and oxycodone hydrochloride. He denied any allergies and smoked cigarettes (1 pack/d). Despite occasional fevers and chills, his review of systems was negative. He denied any recent trauma or systemic illness.

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