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July 2014

Concurrent Primary Vitreoretinal and Spinal Cord Lymphoma: A Unique Entity

Author Affiliations
  • 1Shiley Eye Center, Department of Ophthalmology, University of California, San Diego, La Jolla
  • 2Scripps Memorial Hospital, La Jolla, California
JAMA Ophthalmol. 2014;132(7):902-904. doi:10.1001/jamaophthalmol.2014.419

Primary central nervous system lymphoma is a rare non-Hodgkin B-cell lymphoma limited to the central nervous system and distinct from systemic lymphoma with secondary central nervous system involvement. More than 15% of patients with primary central nervous system lymphoma develop vitreoretinal lymphoma involving the retina and/or vitreous, typically misdiagnosed for autoimmune, infectious, demyelinating, vascular, neoplastic, and paraneoplastic conditions.1 Primary spinal cord lymphoma is a subtype that affects the spinal cord to the exclusion of, or prior to, the brain. Only 35 cases have been reported in the literature,1 none associated with vitreoretinal lymphoma. Herein, we describe the first case of primary spinal cord lymphoma concurrent with primary vitreoretinal lymphoma to our knowledge.

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