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November 2014

Thalidomide for Recalcitrant Nodular Scleritis in Sarcoidosis

Author Affiliations
  • 1Department of Ophthalmology, University of Tennessee College of Medicine, Memphis
JAMA Ophthalmol. 2014;132(11):1377-1379. doi:10.1001/jamaophthalmol.2014.2420

Scleritis is an uncommon manifestation of sarcoidosis. Initial treatment for most patients is systemic corticosteroids, although immunomodulatory therapy is necessary in some patients. Biological response modifiers such as tumor necrosis factor (TNF) antagonists may be useful in patients with scleritis refractory to immunomodulatory therapy.1 Patients who fail therapy with TNF antagonists or experience intolerable adverse effects have limited treatment options. Herein, we describe a patient with cutaneous sarcoidosis and refractory scleritis treated successfully with thalidomide.

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