Endophthalmitis prophylaxis for elective cataract surgery is a subject of considerable debate. The use of perioperative povidone-iodine and an eyelid speculum and drape with isolation of eyelids and eyelashes as well as meticulous sterile preparation and procedures are effective in limiting the incidence of endophthalmitis after cataract surgery.1 The rapid evolution of cataract surgical techniques, including clear-corneal incision, small-incision surgery, and femtosecond lasers, makes it difficult for the published literature to remain relevant to current clinical practices. As many cataract surgeons consider adopting intracameral antibiotics, it becomes important that we recognize the salient issues involved in this important decision.