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Comment & Response
December 2014

Comments on Infant Aphakia Treatment Study 4.5-Year Results

Author Affiliations
  • 1Department of Ophthalmology, Alder Hey Children’s NHS Foundation Trust, Liverpool, England
JAMA Ophthalmol. 2014;132(12):1491-1492. doi:10.1001/jamaophthalmol.2014.3532

To the Editor We read with interest the article on 4.5-year visual acuity outcomes for the Infant Aphakia Treatment Study (IATS).1 This is clearly a well-thought-out and meticulously devised study.

The authors state that the study follows the intention-to-treat principle. We feel that as not all the study participants met the outcome criteria, this study does not fit the definition of an intention-to-treat study, which should include all the participants. For example, only the participants who had at least 3 adherence assessments were included in the analysis.

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