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Comment & Response
January 2015

Could Progressive Outer Retinal Necrosis Begin With Retinal Deep Capillary Ischemia?

Author Affiliations
  • 1Department of Ophthalmology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, China
  • 2Vitreous-Retina-Macula Consultants of New York, New York
JAMA Ophthalmol. 2015;133(1):110-111. doi:10.1001/jamaophthalmol.2014.3548

To the Editor We read with great interest the recent article by Margo and Friedman titled “Progressive Outer Retinal Necrosis (PORN): A Catchy Acronym But Is the Anatomy Correct? The Salient Observation of Lorenz E. Zimmerman, MD.”1 The authors questioned the name of this disease because histological findings indicated that the site of initial necrosis was the inner retina rather than the outer retina. Why would the ophthalmoscopic appearance of this entity give the impression that the early involvement occurs in the outer retina?