[Skip to Navigation]
Invited Commentary
February 2015

Nibbling Away at the Diagnosis of Idiopathic Uveitis

Author Affiliations
  • 1Legacy Devers Eye Institute, Portland, Oregon
  • 2Casey Eye Institute, Oregon Health and Science University, Portland
JAMA Ophthalmol. 2015;133(2):146-147. doi:10.1001/jamaophthalmol.2014.4272

Mrs N fidgeted behind me as I focused the slitlamp beam on her daughter’s eye. “Laura has anterior uveitis,” I pronounced.

“But why, doctor? We eat such a healthy diet,” mom replied and added, with just a hint of pleading in her tone, “We exercise. We avoid stress.”

“I’m afraid it’s idiopathic, Mrs N,” I said. My own response was tinged with regret that I could not be more specific. “We know it’s due to an immune response. But her disease just does not fit into a known niche, so we label it idiopathic.”