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Comment & Response
February 2015

Understanding the Adverse Effects of Ocriplasmin

Author Affiliations
  • 1Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
JAMA Ophthalmol. 2015;133(2):229. doi:10.1001/jamaophthalmol.2014.4484

To the Editor Recent reports of loss of vision after injection of ocriplasmin for vitreomacular traction cite the substrates of this enzyme as fibronectin and laminin.1-3 Not surprisingly, these are the same substrates mentioned in the package insert for this enzyme and are its “intended” targets at the vitreoretinal interface.4 Speculation about the adverse effects of the enzyme focused exclusively on these substrates. The reason for vision loss appears to involve damage to the photoreceptor outer and inner segments, suggesting that ocriplasmin may have broader substrate specificity.

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