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Comment & Response
June 2015

The Orbit and the Brain—Reply

Author Affiliations
  • 1Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark
  • 2Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
  • 3Department of Ophthalmology, Glostrup University Hospital, Glostrup, Denmark
JAMA Ophthalmol. 2015;133(6):727-728. doi:10.1001/jamaophthalmol.2015.0367

In Reply We read with interest Ferreri’s comments on our multicenter work on OA-DLBCL.1 We are pleased to have the opportunity to contribute with further information regarding this uncommon subcategory of extranodal non-Hodgkin lymphoma.

Current information concerning clinical and histopathological characteristics of OA-DLBCL is sparse because investigations often are limited to series of ocular adnexal lymphomas covering a wider range of subtypes.2 Our retrospective international study included 100 patients with OA-DLBCL from 6 eye cancer centers during a 30-year period.1 The nature of this design left us with a relatively large cohort as compared with others, but at the same time we adopted the difficulties of selection bias inherent to our heterogeneous study population.1 Another important bias was related to the fact that staging procedures (eg, Ann Arbor staging) were far more exhaustive in the latter half of the study period.