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Comment & Response
August 2015

Contemplating the Diagnostic Certainty of Primary Iris Mucosa-Associated Lymphoid Tissue Lymphoma

Author Affiliations
  • 1Department of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa
  • 2Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Ophthalmol. 2015;133(8):969-970. doi:10.1001/jamaophthalmol.2015.1153

To the Editor Demirci et al1 reported the successful treatment of a primary B-cell mucosa-associated lymphoid tissue (MALT) lymphoma of the iris with rituximab. The diagnosis was based on fine-needle aspiration (FNA) cytology findings described as “a monomorphic population of small to medium-sized hyperchromatic, CD20+ lymphocytes.”1 A few reactive CD3+ reactive lymphocytes were also observed. The results of other immunohistochemical stains were not reported, nor were any adjunct studies such as flow cytometric immunophenotyping or polymerase chain reaction for IgH gene rearrangement obtained.