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September 2015

Diffuse Pigmentary Retinopathy and Preretinal and Perivascular Intraretinal Invasion of Choroidal Malignant Melanoma

Author Affiliations
  • 1Retina Center of Minnesota, Phillips Eye Institute, Minneapolis
  • 2Midwestern University, Glendale, Arizona
  • 3Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis
JAMA Ophthalmol. 2015;133(9):1092-1094. doi:10.1001/jamaophthalmol.2015.1817

Invasion of the retina by malignant choroidal melanoma is relatively common, occurring in 23% to 40% of enucleated eyes.1,2 Limited invasion typically occurs after the tumor penetrates Bruch’s membrane and migrates into overlying retina. Widespread proliferation of melanoma cells within the vitreous and invasion of nonadjacent retina are rare.1-3 We report a case of malignant melanoma with preretinal membrane proliferation of tumor and perivascular retinal invasion, clinically resembling retinitis pigmentosa.

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