Two brothers in their late teens presented with bilateral eyelid swelling and irritation that had lasted 1 year. There was no history of associated eyelid pain or bleeding. The older brother had an extensive medical history, including dysphonia, oral mucosal lesions, alopecia, recurrent parotitis, vocal cord swelling, and recurrent vesicular eruptions on his face, trunk, and perineum. He had seen several medical specialists and had been comprehensively evaluated for these concerns yet remained undiagnosed since birth. Two skin biopsies were performed at 2 and 6 years of age, but the findings were considered unremarkable.