Seborrheic keratoses (SKs) are common, often numerous lesions of older patients, having a characteristic greasy, stuck-on appearance.1 They are often thought of as universally benign. Development of a malignant tumor within an SK is indeed a rare event.2 To our knowledge, this is the first report of an invasive squamous cell carcinoma (SCC) arising in an SK in the eyelid skin, a reminder that typical-appearing SKs can harbor a malignant neoplasm.