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In the current issue of JAMA Ophthalmology, Sandhu et al1 report a retrospective cohort study of medical claims data in order to determine the association between fluoroquinolones and uveitis. The authors should be commended on their excellent analyses and interpretation of the results. Their study did not find an association between fluoroquinolones and uveitis. Their conclusions are both in keeping and in contrast with the findings of recent similar studies.2,3 The differing conclusions derived from these studies highlight some topics that need to be considered when interpreting the results of medical claims database research: the importance of using proper controls, accounting for confounding bias, replication and validation of results, and the inherent limitations of this type of research.
Forooghian F. Controversy Surrounding the Proposed Ocular Adverse Events of Fluoroquinolones. JAMA Ophthalmol. 2016;134(1):43–44. doi:10.1001/jamaophthalmol.2015.4270
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