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Comment & Response
February 2016

Long-term Risk of Melanoma-Related Mortality After Uveal Melanoma—Reply

Author Affiliations
  • 1Retina Service, Massachusetts Eye and Ear Infirmary, Boston
JAMA Ophthalmol. 2016;134(2):239-240. doi:10.1001/jamaophthalmol.2015.5235

In Reply Kivelä and Kujala caution that the mortality rates calculated using the Kaplan-Meier method may be biased, resulting in an overestimate of risk, and suggest that a competing risks analysis may have yielded more accurate estimates.

They also point out that we may have misinterpreted certain aspects of their long-term study1 because we stated, “Both published studies of very long-term follow-up after enucleation included only patients with 20 years or 25 years of follow-up.”2 We realize that their study described patients who had a minimum of 20 years of follow-up as evidenced by our discussion in the remainder of the paragraph that began with the above statement and elsewhere in the article.2