Phendimetrazine behaves as a sympathomimetic amine and is used as an appetite suppressant.1 We present a case of central retinal vein occlusion (CRVO) that developed after taking phendimetrazine for 2 days. The purpose of this case report is to draw attention to the potential for sight-threatening complications in patients receiving phendimetrazinen, although the event could have been coincidental to its use.